How is ALT (Alternative Lengthening of telomers) similar to and different from normal Double Strand Break...
How is ALT (Alternative Lengthening of telomers) similar to and different from normal Double Strand Break repair by Homologus Recombination?
Homework Answers
answer:
alternative lengthening of telomeres (ALT) is a telomerase-independent but it is a recombinant dependent pathway that functions to maintain telomeres. by some immortal cells, ALTs are used instead of telomerase.
homologous recombination helps the cell to have access and copy intact DNA sequence informationto in order to repair DNA damage affecting both strands of the helix.
unlimitedly proliferating cells need to acquire the telomere DNA maintenace mechanism, to counteract possible shortnening through multiple rounds of replication and segregation of linear chromosomes.ALT depends on the recombination between telomere repetetive DNAs, however the molecular details remain unknown. recent studies have shown that there are prescence of special structures of telomere DNA and genes essential for the phenotype of ALT cells
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How is ALT (Alternative Lengthening of telomers) similar to and
different from normal Double Strand Break...
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