Log (y/1-y) = n(log pO2) - n log P50
log (0.9/1-0.9) = n ( log 26) - (log 77)
0.9542 = 0.4715 n
n = 2.02
So hill cofficient of hb molecule is 2.02.
This is all the information 35. What is the Hill Coefficient of a hemoglobin molecule that...
The Hill plot is shown below for both Hemoglobin (Hb) and
Myoglobin (Mb). What is the value of Hill coefficient for each
protein and how do you interpret each Hill curve? Please work out
how to find n for Hemoglobin.
2. The Hill plot is shown below for both Hemoglobin (Hb) and Myoglobin (Mb). What is the value of Hill coefficient for each protein and how do you interpret each Hill curve? [15] n 42, 43801 Mb X -2 -1...
Which of the following is NOT an indication that the binding of oxygen to hemoglobin is cooperative? a. Oxygen binding of one subunit induces a shift of the other hemoglobin subunits from the T state to the R state. b. A plot of hemoglobin’s fractional saturation against partial pressure of oxygen (Y versus pO2), is sigmoidal rather than hyperbolic. c.Hemoglobin has four subunits, each of which can bind oxygen. d.The Hill coefficient, n, is greater than 1.0.
The measured Hill coefficient for Oz binding to hemoglobin under physiologic conditions, which has four binding sites for O2, is only about 3. Why is this?
In an aqueous solution at 223.15 K, the diffusion coefficient of Hemoglobin (r=35 A with dot on top ) is 7.6x10-14 cm2s-1 and for O2 (r=2.0 A with dot on top ) is 1.2x10-12 cm2s-1. The rate constant for binding O2 to Hemoglobin is 4.0x107 M-1s-1. Is this a diffusion-controlled reaction? Find necessary parameter and explain your opinion.
please answer in details this biophysical chemistry
question
5. The measured Hill coefficient for a binding to hemoglobin under Physiologie conditions, which has four binding site of for a, is only about 3. Why is this?
5. Under normal physiological conditions, hemoglobin is half saturated with O2 at 26 torr, and the Hill coefficient nn = 2.8. What is the degree of saturation when the partial pressure of O2 in the tissue capillaries falls to 33 torr during gentle walking? A. 0.34 B. 0.41 C. 0.56 D. 0.66 E. 1.00
The diffusion coefficient for horse hemoglobin in water is 1.26 × 10–10 m2 s–1 at 40 °C. The viscosity of water at 40 °C is 0.653 × 10–3 kg m–1 s–1. Estimate the radius of hemoglobin assuming the molecule to be spherical and obey Stokes’s law. Comment on the size of Hemoglobin to a corona virus unit which has a diameter of 120 nm.
Please help with all parts... I am a bit confused and the prof
is no help.
20.) A newly discovered oxygen binding protein (OBP) has been discovered. The Hill plot shown below was generated based on the oxygen binding parameters of OBP (dashed lines) and compared to hemoglobin ( solid line). 1 Yoz 1-Y02 Log Log po (a) (2 pts) Which of the two proteins has the higher oxygen affinity? (b) (2 pts) Calculate the hill coefficient for OBP. n...
1. Molecule A has a partition coefficient of 4 and a molecule B has partition coefficient of 2. Which molecule, will move faster across the membrane and why? 2. What is the osmolarity of 2M Fe2(SO4)3solution (write the units too)?
Hemoglobin is a large molecule that carries oxygen in the body. An aqueous solution that contains 2.61 g of hemoglobin in 100.0 mL has an osmotic pressure of 7.52 mmHg at 25°C. What is the molar mass of the hemoglobin? Assume hemoglobin does not dissociate in water. 1.96 x 103 g/mol O 3.65 x 103 g/mol 84.8 g/mol 6.45 x 104 g/mol