Question

Describe, in detail, the synthesis and insertion into the ER membrane of the insulin receptor. This receptor employs the cleavage of an ER Signal sequence and an internal stop-transfer membrane-anchor sequence.

Answer 1

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the ER Membrane synthesis and insertion into ich this insula receptor Insulin is synthesized in significant quan- toties only in ß cells in the pancreas and insolen mRNA is translated as a single chadh precursor called preproinsulin and removal of its signal peptide during insestion into the endoplasmic reti when generates proinsulin and after the synthes they spans the endop laranee reticolour membrane with the same orie- ntation (like appear on plasma meenbrane) N-terminal signal sequence the target to them to end op larmie reticulum and internal stop - tranefer meuchane ancher sequence and it becomes membrane spanning & helix , the signal sequence of endoplasmic reficulum on insolen reeptor is cleaved and chain us ing. growing N-terminus is extruded into the women and 22 ameno acod un the middle of insulin receptor stops the transfer and the internal Sequence be- vents for extrusion and of reacains translocon until synthesis is finished