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Describe, in detail, the synthesis and insertion into the ER membrane of the asialoglycoprotein receptor. This...

Describe, in detail, the synthesis and insertion into the ER membrane of the asialoglycoprotein receptor. This receptor employs an internal signal anchor sequence.

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Proteins with this N cytosol - C luminal orientation have a single internal hydrophobic signal-anchor sequence that functions as both an ER signal sequence and membrane-anchor sequence.
Synthesis and membrane insertion of the asialoglycoprotein receptor and proteins with a similar orientation, which employ an internal signal-anchor sequence. ... In this case, the signal-anchor sequence inserts into the ER membrane with its N-terminus facing the cytosol.

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