What and how is CFTR used in membranes as a Cl- channel? How is it regulated...
What and how is CFTR used in membranes as a Cl- channel? How is it regulated by CAMP
Homework Answers
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated anion channel with two transmembrane domains and two nucleotide binding domains.
Binding ATP to nucleotide binding domain associates these channels thereby opening the pore of the CFTR channels. When ATP is hydrolyzed, the nucleotide binding domains dissociate again and the pore closes.
Activation of the Adenosine A2B receptor by Adenosine leads to stimulation of Adenylate cyclase leading to an increase in cAMP, and subsequent activation of the protein kinase A. Phosphorylation of CFTR channels by PKA causes channel opening.
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What and how is CFTR used in membranes as a Cl- channel? How is
it regulated...
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an...
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an abnormally thick sticky mucus is produced on the outside of the cell. This mucus clogs the airways in the lungs, and increases the risk of infection by bacteria. Figure 2 illustrates a mutant CFTR channel in the epithelial cells lining the lung. Suppose the Na^+ channel in the figure was open. Why would more Na^+ enter a cell with mutant CFTR than a cell...
The CFTR protein is a membrane Cl- transport protein and has a cytosolic regulatory domain that...
The CFTR protein is a membrane Cl- transport protein and has a cytosolic regulatory domain that is phosphorylated by protein kinase A (PKA). PKA phosphorylation has been found to activate the Cl- channel activity of CFTR in lung cells. Secretion of chloride by CFTR is enhanced by binding of epinephrine to the β-adrenergic receptor that couples to Gs, and is inhibited by binding of serotonin to a G-protein coupled receptor (GPCR) that couples to Gi. However, epinephrine and serotonin added...
How does the CFTR protein in cystic fibrosis defect cause an imbalance of Cl- and Na+...
How does the CFTR protein in cystic fibrosis defect cause an imbalance of Cl- and Na+ ions?
Cell membranes contain channels that allow Na+ ions to rush in. Consider a channel that has...
Cell membranes contain channels that allow Na+ ions to rush in. Consider a channel that has a diameter of 2.81 nm and a length of13.0 nm. If the channel has a resistance of 16.5 GΩ, what is the resistivity ? of the solution in the channel?
Cell membranes contain channels that allow ions to cross the phospholipid bilayer. A particular K+ channel...
Cell membranes contain channels that allow ions to cross the phospholipid bilayer. A particular K+ channel carries a current of 1.77 pA . How many K+ ions, ? , pass through the channel in 1.72 ms ?
The CFTR gene is a eukaryotic gene, but how is the gene structured in terms of...
The CFTR gene is a eukaryotic gene, but how is the gene structured in terms of the numbers and lengths of exons and introns? "Sketch" a rough, but labelled diagram of the exon/intron structure of the CFTR gene and explain the significance of exons and introns and what such gene structures mean in terms of gene function. As part of the explanation, address the relationship between allelic variants and gene structure
what is the general structure of detergents? how do these affect membranes and membranes proteins? (this...
what is the general structure of detergents? how do these affect membranes and membranes proteins? (this question is essential cell biology 4th edition chapter 11 membrane structure))
What are SIFIs? How should they be regulated?
What are SIFIs? How should they be regulated?
What is meant by the term metabolic flux, and how is it regulated?
What is meant by the term metabolic flux, and how is it regulated?
6.8 How is a channel defined in FDM? How is a channel defined in TDM? 6.9...
6.8 How is a channel defined in FDM? How is a channel defined in TDM? 6.9 Why is multiplexing viewed as a cost-effective data transmission option by business computer network managers? 6.11 Briefly describe how FDM is used to multiplex analog voice signal? how is it used to multiplex analog cable television channels.
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an abnormally thick sticky mucus is produced on the outside of the cell. This mucus clogs the airways in the lungs, and increases the risk of infection by bacteria. Figure 2 illustrates a mutant CFTR channel in the epithelial cells lining the lung. Suppose the Na^+ channel in the figure was open. Why would more Na^+ enter a cell with mutant CFTR than a cell...
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