Human cells infected by HIV increase the expression of SAMDH1, a phosphohydrolase that removes triphosphate groups...
Human cells infected by HIV increase the expression of SAMDH1, a phosphohydrolase that removes triphosphate groups from dNTP substrates. Explain how SAMDH1 inhibits HIV replication.
Homework Answers
Ans:
SAMDH1 inhibits HIV replication:
- SAMDH1 was recently identified as a novel restrictrion factor in a myeloid cells.
- SAMDH1 inhibits viral replication through an original mechanism: it hydrolyses intracellular dNTPs in non cycling cells, thus decreasing amount of these key substrates, which are required for viral DNA synthesis.
- SAMDH1 deplets levels of dNTPs (deoxynucleoside triphosphate), the precursor for DNA synthesis.
- By maintaining the pool of dNTPs very low, SAMDH1 starves the virus of a building block that is essential for its replication.
- This is great mechanism of defense because macrophage do not divide, thus do not replicate their nuclear DNA and are not affected by dNTPs starvation.
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Human cells infected by HIV increase the expression of SAMDH1, a
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