The amino acid Prolinehas a pk1 of 1.99, pk2 of 10.60. The amino acid Serine has...
The amino acid Prolinehas a pk1 of 1.99, pk2 of 10.60. The amino acid Serine has pk1 of 2.21 and a of pk2 of 9.15. If these two amino acids bind together by peptide bond creating the peptide sequence Pro-Ser . What will be the overall charge of this peptide at the physiological pH of 7?
Homework Answers
At pH = pK half of the dipeptides (Pro-Ser) are deprotonated.
When pH >> pK, then all of the dipeptides are deprotonated.
At pH = 0, both the amine and the carboxylic acid groups will be protonated. Thus, the overall charge on the dipeptide at this pH = +1.
At pH = 7, the amine group will remain protonated but the carboxylic acid groups will be deprotonated.
Therefore, the overall charge of this peptide at the physiological pH of 7 = 0
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The amino acid Prolinehas a pk1 of 1.99, pk2 of 10.60. The amino
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pH 0 =
pH 3 =
pH 5 =
pH 7 =
pH 10 =
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#1) For the following pentapeptide (Where pH =1):
a) What would the net charge be for the following pH?
pH 0 =
pH 3 =
pH 5 =
pH 7 =
pH 10 =
pH 13 =
b) Calculate the pl of the pentapeptide. (Cysteine: pK1 = 1.96,
pK2 = 10.128) ( Glutamine: pK1 = 2.17 , pK2 = 9.13) (Arginine: pK1
= 2.17. pK2 = 9.04) (Leucine: pK1 = 2.36 , pK2 = 9.60)
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