Give the Hardy–Weinberg expected genotypic frequencies for an autosomal locus with three alleles, where the frequencies of alleles A1, A2, and A3 are defined as p, q, and r, respectively. Set the problem up and show your work.
Tay–Sachs disease is an autosomal recessive disorder. Among Ashkenazi Jews, the frequency of Tay–Sachs disease is 1 in 3600. If the Ashkenazi population is mating randomly for the Tay–Sachs gene, what proportion of the population consists of heterozygous carriers of the Tay–Sachs allele?
Answer:
Tay-sachs frequency (tt) = q^2 = 1/3600 = 0.00028
Tay-sachs allele frequency(t) = q = SQRT of q^2 = 0.0167
Normal allele frequency (T)= p = 1- 0.0167 = 0.9833
Heterozygous normal frequency = Tt = 2* 0.9833 * 0.0167 = 0.03284
Give the Hardy–Weinberg expected genotypic frequencies for an autosomal locus with three alleles, where the frequencies...
The incidence of Tay Sachs, an autosomal recessive genetic
disorder, is approximately 1 in 3,500 in a certain population of
Ashkenazi Jews. Assuming Hardy-Weinberg equilibrium, what is the
frequency of carriers for the Tay Sachs allele in this
population?
The incidence of Tay Sachs, an autosomal recessive genetic disorder, is approximately 1 in 3,500 in a certain population of Ashkenazi Jews. Assuming Hardy-Weinberg equilibrium, what is the frequency of carriers for the Tay Sachs allele in this population? OOO 98.5%...
Tay-Sachs disease is an autosomal recessive disorder. Among Ashkenazi Jews of central European ancestry about in 1/3600 children are born with Tay-Sachs disease. What is the frequency for being a carrier for Tay-Sachs in this population? A carrier does not show the trait but can pass it on to his/her offspring.
2) Tay-Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay-Sachs disease occurs at very high frequency in some Central and Eastern European (Ashkenazi) Jewish populations. In certain Ashkenazi populations, 1 in 1000 infants has Tay-Sachs disease. Population biologists believe the high frequency is a consequence of genetic bottlenecks caused by pogroms (genocide) that have reduced the population multiple times in the last several hundred years. a) In the population described,...
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14. Given below are the genotypic frequencies for a single gene
with two alleles for three
different populations:
Population 1
AA
0.25
Aa
0.50
aa
0.25
Population 2 0.35 0.56 0.09
Population 3 0.49 0.42 0.09
Which of the following is NOT a correct statement about these
three populations?
A) Only two of the populations are in Hardy-Weinberg
equilibrium
B) Population 1 is in Hardy-Weinberg equilibrium; the frequency of
allele A is 0.5
C) Population 2 is not in Hardy-Weinberg...
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