Which aminoaciduria translates to "alkali lover"? Which chemical accumulates in the blood, tissues, and urine?
Homework Answers
- Aminoaciduria is a condition in which abnormally increased concentration of amino acids are present in the urine.
- There are many disorders which are collectively known as "Aminoacidurias".
- The major disorders are phenylketonuria (PKU), tyrosyluria and alkaptonuria.
- Alkaptonuria is the aminoaciduria which translates to "alkali lover".
- This is because of the fact that the urine from patients with this condition turns dark after becoming alkaline from standing at room temperature.
- Therefore, the term "alkali lover" or "alkaptonuria" was used to address the condition.
- This condition arises from a metabolic defect which is the 3rd major defect in the phenylalanine-tyrosine pathway.
- Due to this metabolic defect, the patient does not inherit the gene which is needed to produce the enzyme homogentisic acid oxidase.
- Without the enzyme homogentisic acid oxidase, phenylalanine-tyrosine pathway is terminated before reaching completion.
- Therefore, homogentisic acid is the chemical which accumulates in the blood, tissues, and urine.
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Which aminoaciduria translates to "alkali lover"? Which chemical
accumulates in the blood, tissues, and urine?
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