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11. John is suffering from both autosomal dominant deafness (D) and achondroplastic dwarfism (A) and has...

11. John is suffering from both autosomal dominant deafness (D) and achondroplastic dwarfism (A) and has married to a normal woman. Assuming that: a) P=1 for both traits; b) these genes are 20 cM apart on chromosome 9, and c) his father had dwarfism and his mother was deaf, what is the chance that their first child would have both traits? A. 10% B.40% C.45% D.50% E.80% F.100%

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Answer #1

Answer: Option A is correct

Explanation:

John's father = D_aa
John's mother = ddA_
John = DdAa
John's wife = ddaa

Parental cross: DdAa X ddaa
Progeny: DdAa Ddaa ddAa ddaa

It is given that both genes are 20 cM apart on the same chromosome.
D and a are present on paternal chromsome.
d and A are present on maternal chromosome.
i.e. both loci are in repulsion.

Parental combinations = 40%
Recombinants = 20%
So, progeny probabilities are,
DdAa = 10%
Ddaa = 40%
ddAa = 40%
ddaa = 10%

The probability for a child to acquire both the disorders = D_A_ = 10%

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