Question

The following 10 combination therapies, which are among the most important. For each, write out their components and describe the overall function of the combination therapy (is it topoisomerase I inhibition plus topoisomerase II inhibition? Or antimetabolite plus alkylating agent? etc.

(a) BEP:

(b) CHOP:

(c) DCF:

(d) ECF:

(e) EPOCH:

(f) FAC:

(g) FEC:

(h) FOLFIRI:

(i) FOLFIRINOX:

(j) GTX:

Please provide the explanation. Once I read them I want to be familiar with these combination therapies. Thanks

Answer 1

a)BEP is commonly used as a treatment for men with testicular cancer. It's a combination of 3 chemotherapy drugs: B=bleomycin E=etoposide P=platinum (cisplatin) .Doctors may also use BEP to treat a rare type of ovarian cancer called teratoma of the ovary.

b)CHOP is the name of a combination of cancer drugs used to treat non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). It is made up of the drugs:C=cyclophosphamide D=doxorubicin (Adriamycin) V=vincristine (Oncovin) P=prednisolone, which is a steroid

c)DCF D=docetaxel, C=cisplatin F=5-fluorouracil) An abbreviation for a chemotherapy combination used to treat certain types of head and neck cancer and stomach cancer.

d)ECF is the name of a chemotherapy combination.It includes the drugs: E – epirubicin C – cisplatin F – fluorouracil (5FU) .It is treatment for stomach cancer and cancer of the food pipe (oesophagus).

e) EPOCH A chemotherapy regimen consisting of etoposide, prednisone, vincristine (Oncovin), cyclophosphamide and doxorubicin hydrochloride (hydroxydaunorubicin hydrochloride),An abbreviation for a chemotherapy combination used to treat aggressive forms of non-Hodgkin lymphoma, including mantle cell lymphoma.

f)FAC (Fluorouracil, Adriamycin and Cytoxan) is a chemotherapy regimen sometimes given for localized breast cancers with a relatively high risk for recurrence. It is a combination of three chemotherapy medicines:f=Fluorouracil (5-FU) - an antimetabolite chemotherapy medicine A=Doxorubicin (Adriamycin) - an anthracycline C=Cyclophosphamide (Cytoxan) - an alkylating agent

g)FEC is a combination of three chemotherapy drugs used to treat breast cancer. It takes its name from the initials of the drugs:F=5 fluorouracil (also known as 5FU) E=epirubicin C=cyclophosphamide FEC destroys cancer cells by interfering with their ability to divide and grow.

h)FOLFIRI is a combination of chemotherapy drugs and is also known as irinotecan de Gramont or Irinotecan modified de Gramont. It is a treatment for bowel cancer.It’s made up of: folinic acid (also called leucovorin, calcium folinate or FA) fluorouracil (also called 5FU) irinotecan. These cancer drugs destroy quickly dividing cells, such as cancer cells.

i)FOLFIRINOX is the name of a combination of cancer drugs that includes:FOL – folinic acid (also called leucovorin, calcium folinate or FA) F – fluorouracil (also called 5FU I=Irin – irinotecan Ox – oxaliplatin .It is a treatment for advanced pancreatic cancer.

j)GTX

a)BEP is commonly used as a treatment for men with testicular cancer. It's a combination of 3 chemotherapy drugs: B=bleomycin E=etoposide P=platinum (cisplatin). Doctors may also use BEP to treat a rare type of ovarian cancer called teratoma of the ovary.

b)CHOP :CHOP is the name of a combination of cancer drugs used to treat non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). It is made up of the drugs:

• C=cyclophosphamide H-doxorubicin Hydrochloride(Adriamycin) O=vincristine (Oncovin) P=prednisone

d)DCF D= Docetaxel,C= Cisplatin, and F= 5-fluorouracil

chemotherapy combination used to treat certain types of head and neck cancer and stomach cancer. It includes the drugs docetaxel (Taxotere), cisplatin (Platinol), and fluorouracil.

C

P

extracorporeal photopheresis