what is the effect of not having the HDAC7 protein around and active on the CFTR...
what is the effect of not having the HDAC7 protein around and active on the CFTR protein?
Homework Answers
Some functions of HDA (Histone Deacetylase 7) protein are in cell cycle progression, transcriptional regulation and developmental events. And by repressing transcription of myocyte enhancer it results into muscle maturation.
Effects of not having or inactive HDAC 7 are embryonic lethality, consequent dilation and rupture of blood vessels.
HDAC inhibitors corrects the protein misfolding disorder that occurs due to familial and somatic mutation and finally inhibits the formation of CFTR variants.
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what is the effect of not having the HDAC7 protein around and
active on the CFTR...
What is cystic fibrosis? Which amino acid is missing in the CFTR protein in people with...
What is cystic fibrosis? Which amino acid is missing in the CFTR protein in people with cystic fibrosis? What is the function of a normal CFTR protein? What is the malfunction in a CFTR protein in people with cystic fibrosis?
The CFTR protein is a membrane Cl- transport protein and has a cytosolic regulatory domain that...
The CFTR protein is a membrane Cl- transport protein and has a cytosolic regulatory domain that is phosphorylated by protein kinase A (PKA). PKA phosphorylation has been found to activate the Cl- channel activity of CFTR in lung cells. Secretion of chloride by CFTR is enhanced by binding of epinephrine to the β-adrenergic receptor that couples to Gs, and is inhibited by binding of serotonin to a G-protein coupled receptor (GPCR) that couples to Gi. However, epinephrine and serotonin added...
Specific to the CFTR protein in CF, describe how the changes in this protein affects cellular...
Specific to the CFTR protein in CF, describe how the changes in this protein affects cellular function and the patients health.
Question 26 (4 points) Bonus question: The CFTR protein is found in the plasma membrane of...
Question 26 (4 points) Bonus question: The CFTR protein is found in the plasma membrane of individuals unaffected with cystic fibrosis. A common mutation in CFTR causes the protein to be trapped in the ER and eventually degraded. Why does this happen?
What is the gene sequence(FASTA format) and amino acid sequence for the CFTR gene/protein? If you...
What is the gene sequence(FASTA format) and amino acid sequence for the CFTR gene/protein? If you can provide a link to where you find this, that would be amazing!
How does the CFTR protein in cystic fibrosis defect cause an imbalance of Cl- and Na+...
How does the CFTR protein in cystic fibrosis defect cause an imbalance of Cl- and Na+ ions?
3. (1.8 points) The normal CFTR gene contains these six codons near the middle of the...
3. (1.8 points) The normal CFTR gene contains these six codons near the middle of the transcript: AUU UCU VUA GCA AGA GCU... Al The corresponding amino acids in the normal CFTR protein are: (Use either the one-or three-letter amino acid codes A naint mutation changes the last nucleotide from U to C. At the DNA level, this is a transition transversion c) At the protein level, this is a (silent / missense / nonsense/frameshift ) mutation. D) Instead of...
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an...
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an abnormally thick sticky mucus is produced on the outside of the cell. This mucus clogs the airways in the lungs, and increases the risk of infection by bacteria. Figure 2 illustrates a mutant CFTR channel in the epithelial cells lining the lung. Suppose the Na^+ channel in the figure was open. Why would more Na^+ enter a cell with mutant CFTR than a cell...
The lac repressor active site The active site of the lac repressor protein is composed of...
The lac repressor active site The active site of the lac repressor protein is composed of OK Multiple Choice Inces O the protein domain that binds to allolactose. the protein domain that binds to DNA the protein domain that binds to other lac repressors O a glucose binding domain < Prev
What is the difference between passive and active transport? Provide an example of a transport protein...
What is the difference between passive and active transport? Provide an example of a transport protein involved in the passive transport of K+, and one protein involved in the active transport of K+ across the plasma membrane and explain the direction of the flow of K+ in each case (from inside the cell to the outside, or from the outside of the cell to the inside). Also explain for each of your examples if the transport is uniport, symport, or...
Specific to the CFTR protein in CF, describe how the changes in this protein affects cellular function and the patients health.
Question 26 (4 points) Bonus question: The CFTR protein is found in the plasma membrane of individuals unaffected with cystic fibrosis. A common mutation in CFTR causes the protein to be trapped in the ER and eventually degraded. Why does this happen?
3. (1.8 points) The normal CFTR gene contains these six codons near the middle of the transcript: AUU UCU VUA GCA AGA GCU... Al The corresponding amino acids in the normal CFTR protein are: (Use either the one-or three-letter amino acid codes A naint mutation changes the last nucleotide from U to C. At the DNA level, this is a transition transversion c) At the protein level, this is a (silent / missense / nonsense/frameshift ) mutation. D) Instead of...
If the CFTR doesn't work correctly due to a mutation, Cl^- movement is blocked and an abnormally thick sticky mucus is produced on the outside of the cell. This mucus clogs the airways in the lungs, and increases the risk of infection by bacteria. Figure 2 illustrates a mutant CFTR channel in the epithelial cells lining the lung. Suppose the Na^+ channel in the figure was open. Why would more Na^+ enter a cell with mutant CFTR than a cell...
The lac repressor active site The active site of the lac repressor protein is composed of OK Multiple Choice Inces O the protein domain that binds to allolactose. the protein domain that binds to DNA the protein domain that binds to other lac repressors O a glucose binding domain < Prev
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