What are the consequences of the missense mutations in BCR-ABLT315I and BRAFV600E?
A. Both missense mutations convert drug-sensitive oncogenes to drug-resistant oncogenes.
B. Both missense mutations convert two proto-oncogenes to oncogenes.
C. Both missense mutations generate constitutively active tyrosine oncokinases.
D. BCR-ABLT315I converts a drug-sensitive oncogene to a drug-resistant oncogene. BRAFV600E converts a proto-oncogene to an oncogene.
E. Both missense mutations convert drug-sensitive oncogenes to drug-resistant oncogenes.
What are the consequences of the missense mutations in BCR-ABLT315I and BRAFV600E? A. Both missense mutations...
3) Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms is not likely to contribute to conversion to an oncogene? Select one: A: Extra copies of the gene are made, thereby enhancing expression. B: A mutation occurs upstream of the gene that results in a more active promoter. C: Chromosomes break and fragments are translocated from one chromosome to another. D: Point mutations occur that result in a protein more resistant to degradation. E: All...
Cancer and Gene Regulation Why is a cell cycle control system needed for cell division? What happens when cells do NOT respond to the cell cycle control system and divide excessively? Tumor Proto-oncogeno (for protein that stimulates coll division) 6 Y DNA Benign Tumor= Mutation withln a control region of DNA Malignant Tumor Mutated promoter Metastasis Normal growth-stimulating protein in excess Oncogene Tumor-Suppressor Genes Proto-oncogene utled tara gese Samor-auppresr gane Many proto-oncogenes code for growth factors /Deletive nonimenig Normel grewt...
Predict the consequences of a temperature sensitive mutation in which the phosphorylation of the β-catenin protein is blocked. Above the permissive temperature: A. β-catenin levels will increase and β-catenin will be constitutively active. B. β-catenin levels will increase and β-catenin will be inactive. C. β-catenin levels will decrease and β-catenin will be constitutively active. D. β-catenin levels will decrease and β-catenin will be inactive. E. β-catenin levels will remain constant but cells will be unresponsive to Wnt signaling.
1) In both eukaryotes and prokaryotes, gene expression can be regulated at the level of ____. Group of answer choices a)transcription b)translation c)mRNA splicing d)All of the above e)transcription and translation only 2)Which of the following is the least likely mechanism to convert a proto-oncogene to an oncogene? Group of answer choices a)gene amplification b)point mutation within the gene c)point mutation in the promoter or enhancer regions d)histone acetylation e)chromosome translocation
How many single base change missense mutations are possible for codon ATG resulting in how many different amino acids? A. 3, 3 B. 5, 3 C. 7, 4 D. 8, 5 E. 9, 6
Please help with answers to these questions
answer the ones that are straightforward like this one
Question 24 5 pts 1. Beta-catenin is classified as a proto-oncogene and APC is classified as a tumor suppressor gene. Both are important parts of the Wnt signaling pathway. Describe the relationship between beta-catenin and APC. Explain in detail why they are classified as a proto-oncogene or tumor suppressor gene. 2. Suppose you're working in a cancer research lab and discover a small molecule...
. Gleevec (Imatinib) inhibits protein kinase BCR-ABL, which is
constitutively active in patients with Chronic Myelogenous Leukemia
(CML). The structure of Gleevec is shown below:
a) Based on our discussion in lecture and the structure above,
explain how the “lead” compound structure for Gleevec was designed
and how it led to the development a compound that could bind ABL
with higher affinity than ATP.
b) Using a broad kinase inhibition assay, you discover that
Gleevec inhibits another tyrosine kinase called...
What type of physical mutations are most likely to cause an amorph? O A nonsense 0 B missense - nonsynomous 0 C missense - synomous O D silent O E polymorphism
Which of the following are consequences of unequal recombination? Deletions Inversions Duplications Transformations Mutations All the above Answers (A) and (D) Answers (A), (B), and (C) Answers (A), (B), (C), and (E)
Q12 Homework. Unanswered What type of physical mutations are most likely to cause a hypermorph? O A nonsense O B missense-nonsynomous O C missense - synomous o D silent O E polymorphism 0 F frameshift