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What is similar and what is different between the redox reactions that occur in beta oxidation...

What is similar and what is different between the redox reactions that occur in beta oxidation versus FA synthesis?
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Answer #1

Difference between fatty acid synthesis and beta oxidation.

1. Fatty acid synthesis takes place in cytoplasam of prokaryotes, whereas beta oxidation takes place in mitochondrial matrix of eukaroytes.

2. The enzymes of fatty acid synthesis are joined in a single polypeptide chain called as fatty acid synthase whereas in beta oxidation, the degardative enzymes are not associated.

3. Products formed/ Intermediates formed in fatty acid synthesis are linked to the sulfhydryl group of ACP (Acyl Carrier Protein) through covalent bond where as in beta oxidation the intermediates are attached to sulfhydryl group of Coenzyme A.

4. The reduction in fatty acid synthesis is NADPH whereas the oxidants in beta oxidation (fatty acid degradation) are FAD and NAD+.

5. The energy requirement in fatty acid synthesis is 49 ATP equivalents whereas in beta oxidation 33 ATP equivalents are released.

The similarities between beta oxidation and fatty acid synthesis are:

1. Oxidation of FAD

2. The hydration

3. Oxidation of NAD+

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