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We're considering a fully recessive, deleterious (harmful) mutation (A2) at an allele frequency of q =...

We're considering a fully recessive, deleterious (harmful) mutation (A2) at an allele frequency of q = 0.01 (one percent) in a large outbreeding population. Thus p(A1) = 0.99.

1. What is the population frequency of A2A2 homozygotes?

2. What is the population frequency of A1A2 heterozygotes?

3. Of all the A2 alleles in the population, what proportion are in heterozygotes?

4. And what proportion are in homozygotes?

5. Now, your country starts a policy of sterilizing all the affected individuals (the A2A2 homozygotes). Next generation, what is expected frequency of the A2 allele (q')?

6. After this enormous and highly unpopular effort, what fraction of the original A2 alleles are still present in the population? (This is q'/q.)

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