Methotrexate competitively inhibits dihydrofolate reductase. Explain why this interferes with tetrahydrofolate synthesis.
Homework Answers
Following is the reaction catalyzed by dihydrofolate reductase
Dihydrofolic acid+NADPH----->tetrahydrofolate + NADP+
So the enzyme is responsible for converting dihydrofolate to tetrahydrofolate. If the enzyme is inhibited by the methotrexate the above reaction can't proceed and tetrahydrofolate can't be synthesized.
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Methotrexate competitively inhibits dihydrofolate reductase.
Explain why this interferes with tetrahydrofolate synthesis.
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Which compound is involved in reducing levels of homocysteine in the blood? Cysteine Adenosine Serine N5, N10-methylene tetrahydrofolate Methionine Methotrexate inhibits purine synthesis by targeting formation of: N10-formyl-tetrahydrofolate from tetrahydrofolate and formate. Folic acid from PABA and pteridine precursor. S-adenosylmethionine from methionine. Tetrahydrofolate from dihydrofolate.
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Description: Case connections are short scenarios or puzzles based on the information from the current unit of study. For the Unit 1 Case Connections assignment, you will choose two...
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Description: Case connections are short scenarios or puzzles based on the information from the current unit of study. For the Unit 1 Case Connections assignment, you will choose two...
i) When dihydrofolate reductase (10 Hg) was assayed in a total volume of 1 ml with 100 uM of dihydrofolate and 80 HM of deoxytubulosine, the enzyme activity was completely inhibited. After dialysi...
i) When dihydrofolate reductase (10 Hg) was assayed in a total volume of 1 ml with 100 uM of dihydrofolate and 80 HM of deoxytubulosine, the enzyme activity was completely inhibited. After dialysis of the assay mixture, enzyme activity was fully restored. What does this tell you about the mode of inhibition by deoxytubulosine irreversible or reversible? For your answer, illustrate how this type of inhibition could occur. [2 marks] v) Suggest TWO types of binding interactions that may take...
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Please follow the instructions and give clear, detailed and
explained solution.
You will need to describe why your chosen answer is correct
while also discussing why the other answers are incorrect.
no copying from internet please.
*********TYPED PLEASE. NOT HAND
WRITTEN.*********
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WRITTEN.****************
******TYPED PLEASE. NOT HAND
WRITTEN.**************
Description: Case connections are short scenarios or puzzles based on the information from the current unit of study. For the Unit 1 Case Connections assignment, you will choose two...
Please follow the instructions and give clear, detailed and
explained solution.
You will need to describe why your chosen answer is correct
while also discussing why the other answers are incorrect.
no copying from internet please.
*********TYPED PLEASE. NOT HAND
WRITTEN.*********
****TYPED PLEASE. NOT HAND
WRITTEN.****************
******TYPED PLEASE. NOT HAND
WRITTEN.**************
Description: Case connections are short scenarios or puzzles based on the information from the current unit of study. For the Unit 1 Case Connections assignment, you will choose two...
i) When dihydrofolate reductase (10 Hg) was assayed in a total volume of 1 ml with 100 uM of dihydrofolate and 80 HM of deoxytubulosine, the enzyme activity was completely inhibited. After dialysis of the assay mixture, enzyme activity was fully restored. What does this tell you about the mode of inhibition by deoxytubulosine irreversible or reversible? For your answer, illustrate how this type of inhibition could occur. [2 marks] v) Suggest TWO types of binding interactions that may take...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25°C, 30°C, and 37°C yielded dissociation constants (Ks) of 2.5 x 10* M, 1.5 x 10*, and 1.0 x 10* M, respectively, for the HMG- CoA reductase-inhibitor complex a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel or...
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