The reaction catalyzed by malate dehydrogenase, Malate + NAD+ → oxaloacetate + NADH + H+ has...
The reaction catalyzed by malate dehydrogenase, Malate + NAD+ → oxaloacetate + NADH + H+ has a ΔG°′ value of +29.7 kJ · mol−1. (a) Would this reaction occur spontaneously in a cell? (b) How does the citrate synthase reaction (described in Problem 7) promote the malate dehydrogenase reac- tion in the cell? What is the overall change in free energy for the two reactions?
7. Citrate synthase catalyzes the reaction
Oxaloacetate + acetyl-CoA → citrate + HS-CoA
The standard free energy change for the reaction is −31.5 kJ ·
mol−1. (a)
Calculate the equilibrium constant for this reaction at 37°C. (b)
Would
you expect this reaction to serve as a control point for its
pathway (the
citric acid cycle)?
Homework Answers
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The reaction catalyzed by malate dehydrogenase, Malate + NAD+ →
oxaloacetate + NADH + H+ has...
3. (10 pts) Citrate synthase catalyzes the reaction: Oxaloacetate + acetyl – COA → citrate +...
3. (10 pts) Citrate synthase catalyzes the reaction: Oxaloacetate + acetyl – COA → citrate + HS – COA The standard free energy change for the reation is -31.5 k] . mol-1. a) Calculate the equilibrium constant for this reaction at 37°C. b) Would you expect this reaction to serve as a control point for its pathway (the citric acid cycle)?
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the...
Consider the malate dehydrogenase reaction from the citric acid
cycle. Given the listed concentrations, calculate the free energy
change for this reaction at energy change for this reaction at 37.0
∘ C (310 K). Δ G ∘ ′ for the reaction is + 29.7 kJ/mol . Assume
that the reaction occurs at pH 7.
thank you
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy...
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the...
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy change for this reaction at 37.0°C (310 K), AG'' for the reaction is +29.7 kJ/mol. Assume that the reaction occurs at pH 7. (malate) = 1.33 mm [oxaloacetate] = 0.200 mm [NAD) - 440 mm [NADH) - 180 mM AG: 36.9 KJ-mol-
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the...
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy change for this reaction at 37.0°C (310 K). AG' for the reaction is +29.7 kJ/mol. Assume that the reaction occurs at pH 7. [malate) = 1.43 mm [oxaloacetate) = 0.150 mM [NAD+] = 220 mm [NADH] = 88 mm kJ.mol-1 AG:
QUESTION 8 Consider the reaction: Malate + NAD → Oxaloacetate + NADH (AG'º = +29.7 kJ/mol)...
QUESTION 8 Consider the reaction: Malate + NAD → Oxaloacetate + NADH (AG'º = +29.7 kJ/mol) A cell at 25°C has the following concentrations of these compounds: malate = 0.5 mm oxaloacetate=0.00002 mM • NAD = 1 mM NADH = 0.04 mm . Is the reaction spontaneous? QUESTION 9 Consider the reaction: 1,3-Bisphosphoglycerate (1,3-BPG) + ADP→ 3-Phosphoglycerate (3-PG) + ATP (AG' = -18.9 kJ/mol) A cell at 25°C has the following concentrations of these compounds: 1,3-BPG = 0.003 Mm ADP...
Malate dehydrogenase catalyses the reaction L-malate + NAD+ <==> oxaloacetate + NADH + H+ and the following results were obtained, calculate Km and Vmax?
Malate dehydrogenase catalyses the reaction L-malate + NAD+ <==> oxaloacetate + NADH + H+ and the following results were obtained, calculate Km and Vmax?
not sure about reaction 3 and 4 acetyl-CoA COA The reactions of the citric acid cycle...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column to the appropriate blanks in the sentences on the right. View Available Hint(s) Reset Help isocitrate dehydrogenase aconitase citrate synthase fumarate hydratase succinate dehydrogenase succinyl-CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase In step 1, oxaloacetate condenses with acetyl-CoA to form citrate, which is catalyzed by...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Calculate AE for the following reaction; Oxaloacetate + NADH Malate + NAD+ E'' (Oxaloacetate /malate) =...
Calculate AE for the following reaction; Oxaloacetate + NADH Malate + NAD+ E'' (Oxaloacetate /malate) = -0.15V 2e ; E (NAD+/NADH) = -0.32V 2e +0.17V -0.32V -0.477 +0.47V -0.17V
3. (10 pts) Citrate synthase catalyzes the reaction: Oxaloacetate + acetyl – COA → citrate + HS – COA The standard free energy change for the reation is -31.5 k] . mol-1. a) Calculate the equilibrium constant for this reaction at 37°C. b) Would you expect this reaction to serve as a control point for its pathway (the citric acid cycle)?
Consider the malate dehydrogenase reaction from the citric acid
cycle. Given the listed concentrations, calculate the free energy
change for this reaction at energy change for this reaction at 37.0
∘ C (310 K). Δ G ∘ ′ for the reaction is + 29.7 kJ/mol . Assume
that the reaction occurs at pH 7.
thank you
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy...
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy change for this reaction at 37.0°C (310 K), AG'' for the reaction is +29.7 kJ/mol. Assume that the reaction occurs at pH 7. (malate) = 1.33 mm [oxaloacetate] = 0.200 mm [NAD) - 440 mm [NADH) - 180 mM AG: 36.9 KJ-mol-
Consider the malate dehydrogenase reaction from the citric acid cycle. Given the listed concentrations, calculate the free energy change for this reaction at energy change for this reaction at 37.0°C (310 K). AG' for the reaction is +29.7 kJ/mol. Assume that the reaction occurs at pH 7. [malate) = 1.43 mm [oxaloacetate) = 0.150 mM [NAD+] = 220 mm [NADH] = 88 mm kJ.mol-1 AG:
QUESTION 8 Consider the reaction: Malate + NAD → Oxaloacetate + NADH (AG'º = +29.7 kJ/mol) A cell at 25°C has the following concentrations of these compounds: malate = 0.5 mm oxaloacetate=0.00002 mM • NAD = 1 mM NADH = 0.04 mm . Is the reaction spontaneous? QUESTION 9 Consider the reaction: 1,3-Bisphosphoglycerate (1,3-BPG) + ADP→ 3-Phosphoglycerate (3-PG) + ATP (AG' = -18.9 kJ/mol) A cell at 25°C has the following concentrations of these compounds: 1,3-BPG = 0.003 Mm ADP...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column to the appropriate blanks in the sentences on the right. View Available Hint(s) Reset Help isocitrate dehydrogenase aconitase citrate synthase fumarate hydratase succinate dehydrogenase succinyl-CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase In step 1, oxaloacetate condenses with acetyl-CoA to form citrate, which is catalyzed by...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Calculate AE for the following reaction; Oxaloacetate + NADH Malate + NAD+ E'' (Oxaloacetate /malate) = -0.15V 2e ; E (NAD+/NADH) = -0.32V 2e +0.17V -0.32V -0.477 +0.47V -0.17V
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