Question

Why do you think that high-throughput sequencing and mapping sequences to a genome is necessary in bioinformatics?

Answer 1

The high throughput sequencing and mapping sequence to genome is important in bioinformatics as it helps in sequencing large number of sequences. It helps in finding out the nucleotides and the quantitative trait gene. There are many types of high throughput methods which are able to sequence long and millions of sequences rapidly. These techniques have revolutionized the studies involving gene sequencing because of the precision of sequencing and its accuracy. They are able to run thousands or millions of reactions at one time and hence it has helped in reducing the time and effort required for sequencing. It helps in also making a comparison between different sequences. The reason why HTS and mapping sequences to a genome is important is because HTS helps in sequencing multiple DNA molecules simultaneously and hence millions of DNA is sequenced at the same time. After the sequencing is over, it helps in mapping the sequence through which short read or sequences are aligned together and compared to a reference sequence. This would help in compiling the whole of the sequence and putting them together to form a complete genome. Hence it helps in finding a whole genome sequence accurately and quickly through multiple sequence comparison and its mapping.