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What is the mechanism by which the gene Kan confers resistance to kanamycin?

What is the mechanism by which the gene Kan confers resistance to kanamycin?

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The mechanism by which the gene Kan confers resistance to kanamycin is by protoplast regeneration in the kanamycin(KM)- hyper-resistance of Streptomyces griseus SS-1198PR and NP1-1PR.

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