Why reovirus virion has no more than 12 dsRNA segments? What is the relationship between 12...
Why reovirus virion has no more than 12 dsRNA segments? What is the relationship between 12 dsRNA segment and its RNA polymerase?
Homework Answers
The genomes of reoviruses comprise either 12 RNA segments. These segments are numbered according to their electrophoretic mobility in gels, the slowest being segment 1. Segments 2, 3 and 8 encode structural proteins; the outer capsid protein encoded by segment 2 is essential for vector transmission. The products of segments 1, 5, 7 and possibly one of the products of segment 12 are involved with RNA replication, and those of segments 4, 6, 9, 10, 11 and one encoded by segment 12 are classed as non-structural proteins.
RNA viruses encode their own RNA-dependent RNA polymerase (RdRp) to transcribe viral mRNA. dsRNA viruses contain an RdRp that is carried into the cell within the virion for transcription to occur.
Adapted from from Fig. 1 of Tao et al., 2010. PLoS Pathogens 6(7), e1000943
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