Question

1. Why is it relatively easy to treat bacterial infections?
2. How does empirical therapy differ from directed therapy?
3. What is the difference between a bacteriocidal agent and a bacteriostatic agent?
4. Under what circumstances are bacteriocidal agents required? Why?
5. Combination treatment
6. Bacterial resistance to antibiotics
   1. Major mechanisms of resistance (Diagram)
      1. Development of altered receptors or targets to which drugs can not bind
      2. Decrease intercellular drug concentration
      3. Reduce uptake
      4. Increase efflux
      5. Enhanced destruction or inactivation (β-lactamase)
      6. Development of resistant metabolic pathways

Answer 1

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