Protein C carries a mutation that causes it to have an endoplasmic reticulum signal peptide at...
Protein C carries a mutation that causes it to have an endoplasmic reticulum signal peptide at its N-terminus, and a nuclear localization sequence at its C-terminus. In which organelle is the translated protein going to end up? Why?
Homework Answers
The mutant protein C is targeted to endoplasmic reticulum. Protein are synthesized from N to C terminus. Hence, N terminus is first synthesized. Presence of the N terminal signal peptide will direct the protein to the Endoplasmic reticulum. The N terminal signal peptide will direct it to the Endoplasmic reticulum as it is bound by signal recognition particle. As the nuclear localization sequence is present at C terminus, it is never used. Hence, the protein remains in ER and is not targeted to nucleus. Only protein that lack N terminal signal peptide remain in cytosol, from where they can enter the nucleus, if they have NLS.
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Protein C carries a mutation that causes it to have an
endoplasmic reticulum signal peptide at...
Please answer all questions 2 After isolating the rough endoplasmic reticulum from the rest of the...
Please answer all questions
2 After isolating the rough endoplasmic reticulum from the rest of the cytoplasm, you purify the RNAS attached to it. Which of the following proteins do you expect the RNA from the rough endoplasmic reticulum to encode? (a) (c) soluble secreted proteins plasma membrane proteins ER membrane proteins all of the above (b) (d) -13 In which cellular location would you expect to find ribosomes translating MRNAS that encode ribosomal proteins? (a) (c) the nucleus in...
64. Which organelle has its own genetic information? a. endoplasmic reticulum b. ribosome c. mitochondrion d....
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Which one of the following statements is false? rough endoplasmic reticulum (RER) does not contain ribosomes...
Which one of the following statements is false? A. rough endoplasmic reticulum (RER) does not contain ribosomes on its surface and is involved in phospholipid synthesis B. an organelle is a specialized structure with specific cellular functions C.the secretory pathway explains the movement of secretory proteins from the endoplasmic reticulum to the Golgi apparatus D. the signal sequence is cleaved by signal peptidase and released into the ER lumen E.signal recognition particles are composed of proteins and RNA that binds to signal sequences and targets...
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hich of the following organelles are the destination for proteins synthetized by cytosolic ribosomes Peroxisomes, endoplasmic...
hich of the following organelles are the destination for proteins synthetized by cytosolic ribosomes Peroxisomes, endoplasmic reticulum, and the Golgi apparatus The Golgi apparatus, lysosomes, and the nucleus Peroxisomes, mitochondria, and lysosomes Peroxisomes, mitochondria, and the nucleus Mitochondria, lysosomes, and the nucleus What is the fate of N-terminus signal peptide after it directs the protein to the ER translocator O It is linked to the transported protein by S-S bond It is cleaved and then released into the membrane It...
Answer and explain why 27) Consider a protein that contains an ER signal sequence at its...
Answer and explain why
27) Consider a protein that contains an ER signal sequence at its N-ter- minus and a nuclear localization se- quence in its middle. What do you think the fate of this protein would be? Briefly explain your answer
A protein that has an internal ER-signal sequence and a nuclear localization might end up in...
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QUESTION 12 The UUUUUUU sequence at the terminus of each gene of the rabiesvirus genome causes...
QUESTION 12 The UUUUUUU sequence at the terminus of each gene of the rabiesvirus genome causes which of the following to occur O A allows DNA synthesis without a primer B. causes RNA-dependent RNA polymerase to stutter OC makes the RNA resistant to RNase H D. allows ribosomes to initiate translation without a cap group E. causes ribosomes to stutter and frameshift QUESTION 13 Poxvirus obtains its innermost membrane from: A. vesicles between the rough endoplasmic reticulum and the Golgi...
5. Shown below is a transmembrane protein (thick line) that was inserted into the endoplasmic reticulum...
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Please answer all questions
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64. Which organelle has its own genetic information? a. endoplasmic reticulum b. ribosome c. mitochondrion d. golgi apparatus e. lysosome 65. Which organelle is a series of interconnected membranous canals or channels that run throughout the cytoplasm of the cell? a. golgi apparatus b. peroxisome c. mitochondrion d. endoplasmic reticulum 66. Which organelle is a composed of a double membrane structure with the inner membrane folded to form cristae? a. Lysosome b. endoplasmic reticulum c. mitochondrion d. ribosome 67. How...
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Scientists want to design fluorescent marker proteins for different cellular compartments using the Green Fluorescent Protein (GFP). This means that the GFP will be targeted and glow at the organelle of interest and they can use these to mark different organelles during fluorescence microscopy. To make these marker proteins, they take the sequence of GFP and add the desired sorting signal. A. GFP on its own is an excellent protein to use as an organelle marker protein because it is...
hich of the following organelles are the destination for proteins synthetized by cytosolic ribosomes Peroxisomes, endoplasmic reticulum, and the Golgi apparatus The Golgi apparatus, lysosomes, and the nucleus Peroxisomes, mitochondria, and lysosomes Peroxisomes, mitochondria, and the nucleus Mitochondria, lysosomes, and the nucleus What is the fate of N-terminus signal peptide after it directs the protein to the ER translocator O It is linked to the transported protein by S-S bond It is cleaved and then released into the membrane It...
Answer and explain why
27) Consider a protein that contains an ER signal sequence at its N-ter- minus and a nuclear localization se- quence in its middle. What do you think the fate of this protein would be? Briefly explain your answer
A protein that has an internal ER-signal sequence and a nuclear localization might end up in the extracellular matrix. in the cytosol. inside a lysosome. o in the plasma membrane.
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