What would be the consequence if we evolved cells lacking 2,3–BPG?
What would be the consequence if we evolved cells lacking 2,3–BPG?
Homework Answers
2,3-BPG is a regulator of oxygen binding to hemoglobin . It binds to the deoxygenated hemoglobin at the centre in the pocket formed by 2 beta globin chains . This site contains many positively charged amino acids which forms bond with negatively charged phosphate groups of 2,3-BPG . Binding of 2,3-BPG to hemoglobin decreases its affinity for oxygen and thus results in the dissociation of oxygen from hemoglobin when there is a need to transport oxygen to the neighbouring tissues (oxygen unloading ). If the cell will lack 2,3-BPG then the oxygen after binding to the hemoglobin strongly will not be dissociated at the time of need by the cells and tissues which will ultimately lead to cell and tissue death due to lack of oxygen .Thus, this activity is due to the effect of 2,3-BPG on transport of oxygen from hemoglobin to tissues . Generally, binding of 2,3-BPG shifts the the oxygen hemoglobin dissociation curve towards right due to decreasing affinity of hemoglobin for oxygen.
2) We discussed in class how the molecule 2,3-bisphosphoglycerate (BPG) is an inhibitor of hemoglobin (Hb)....
2) We discussed in class how the molecule 2,3-bisphosphoglycerate (BPG) is an inhibitor of hemoglobin (Hb). Answer the following questions about BPG and its regulation of oxygen binding: a) Would BPG have any effect on myoglobin’s ability to bind or release oxygen? If so, describe how BPG would affect myoglobin. If not, why? b) Based on the observation that BPG binds preferentially to partially deoxygenated Hb, briefly explain (1-2 sentences) where BPG is most likely to be most effective on...
2,3-BPG is a product of glycolysis, consequently, it can be metabolized as a part of glycolysis...
2,3-BPG is a product of glycolysis, consequently, it can be metabolized as a part of glycolysis when glycolytic intermediates are low. Blood that has been stored for long periods of time may be low in 2,3-BPG (for this reason) if no precautions are taken. What happens if such blood is used in transfusion?
Following intensive exercise, which of the following would be expected to occur? A.Increased production of 2,3-BPG...
Following intensive exercise, which of the following would be expected to occur? A.Increased production of 2,3-BPG B. Decreased hemoglobin affinity for oxygen C. Allosteric inhibition of hemoglobin via binding of H+ ions D. All of the above 2. A high concentration of H+ ions will have what kind of effect on the hemoglobin oxygen dissociation curve? a - A shift to the right A shift to the left b- No effect c- It is not possible to predict with the...
How are the functions of stomata and guard cells related and what would be the consequence...
How are the functions of stomata and guard cells related and what would be the consequence if those cells did not function property? Select one: a. Guard cells are responsible for opening and closing the stomata, and if the stomata did not function then gas exchange and transpiration will not occur through these cells b. Guard cells are responsible for opening and closing of the stomata, and if the guard cells did not function then gas exchange and transpiration will...
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QUESTION 2 What qualitative effect would you expect each of the following to have on the...
QUESTION 2 What qualitative effect would you expect each of the following to have on the Pso of hemoglobin? Explain. a. Increase in pH from 7.2 to 7.4 b. Increase in Pco, from 20 to 40 mm Hg c. Dissociation into monomer polypeptide chains d. Decrease in 2,3-BPG concentration from 7 mM to 5 mM in red cells.
Question 31 6 pts 16) Some patients with erythrocytosis (excess Red Blood Cells) have a mutation...
Question 31 6 pts 16) Some patients with erythrocytosis (excess Red Blood Cells) have a mutation that converts a Lysine to Alanine at residue 82 in the beta-subunit of hemoglobin. This particular Lysine normally protrudes in the central cavity of deoxyhemoglobin, where it participates in binding 2,3,-bisphosphoglycerate (BPG). What effect would you predict this mutation will have on a) the affinity of hemoglobin for BPG and for b) the affinity of hemoglobin for Oxygen in patients with erythrocytosis? Briefly explain...
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How are the functions of stomata and guard cells related and what would be the consequence if those cells did not function property? Select one: a. Guard cells are responsible for opening and closing the stomata, and if the stomata did not function then gas exchange and transpiration will not occur through these cells b. Guard cells are responsible for opening and closing of the stomata, and if the guard cells did not function then gas exchange and transpiration will...
QUESTION 2 What qualitative effect would you expect each of the following to have on the Pso of hemoglobin? Explain. a. Increase in pH from 7.2 to 7.4 b. Increase in Pco, from 20 to 40 mm Hg c. Dissociation into monomer polypeptide chains d. Decrease in 2,3-BPG concentration from 7 mM to 5 mM in red cells.
Question 31 6 pts 16) Some patients with erythrocytosis (excess Red Blood Cells) have a mutation that converts a Lysine to Alanine at residue 82 in the beta-subunit of hemoglobin. This particular Lysine normally protrudes in the central cavity of deoxyhemoglobin, where it participates in binding 2,3,-bisphosphoglycerate (BPG). What effect would you predict this mutation will have on a) the affinity of hemoglobin for BPG and for b) the affinity of hemoglobin for Oxygen in patients with erythrocytosis? Briefly explain...
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