2. In a hypothetical case-control study of 180 cases of heart disease and 300 unmatched controls, the following 2x2 table was determined for the association of sedentary lifestyle with heart disease:
|
Cases |
Controls |
|
|
Sedentary lifestyle |
135 |
150 |
|
Not sedentary lifestyle |
45 |
150 |
|
180 |
300 |
(a) Compute the odds ratio for sedentary lifestyle and heart disease.
2. In a hypothetical case-control study of 180 cases of heart disease and 300 unmatched controls,...
. In a hypothetical case-control study of 180 cases of heart disease and 300 unmatched controls, the following 2x2 table was determined for the association of sedentary lifestyle with heart disease: Cases Controls Sedentary lifestyle 135 150 Not sedentary lifestyle 45 150 180 300 (a) Compute the odds ratio for sedentary lifestyle and heart disease. (b) There is concern that sex may be a confounder in the relationship between sedentary lifestyle and heart disease. What three conditions must...
Suppose you conduct a case-control study of endometrial cancer, with 200 cases and 200 unmatched controls. According to medical records (which we will assume are correct), 150 of the cases and 100 of the controls have used postmenopausal estrogens. (a) Construct the appropriate 2x2 table, and compute and interpret the odds ratio for endometrial cancer associated with postmenopausal estrogen use.
When the subjects were stratified by sex, the following tables were obtained: Females: Cases Controls Sedentary lifestyle 15 30 Not sedentary lifestyle 30 120 45 150 Males: Cases Controls Sedentary lifestyle 120 120 Not sedentary lifestyle 15 30 135 150 (d) Does the relationship between sedentary lifestyle and heart disease appear to differ for females and males? (That is, is there an interaction between sex, sedentary lifestyle, and heart disease?) Why or why not?
6. A case-control study of 1700 participants looked at the association between Tamoxifen and uterine cancer. The study included 689 cases. There were 139 cases and 58 controls using Tamoxifen. Fill in the 2x2 table. Calculate and interpret the odds ratio.
A case-control study was conducted to determine the association between smoking and coronary heart disease. The investigators found an odds ratio of 1.8 for coronary heart disease among subjects who smoked compared to those who didn’t smoke. The 95% confidence interval for this odds ratio was 0.8-4.3 and the P-value was 0.10. 1. State in words your interpretation of the odds ratio. 2. State in words your interpretation of the 95% confidence interval. 3. State in words your interpretation of...
Read the following research study and answer the following questions: A case control study was conducted to evaluate the relationship between direct sun exposure and skin cancer. 150 Cases and 100 controls were recruited from Al Wehda hospital. A data collecting method was distributed among both controls and cases. Analysis of data revealed that 70 of cases were exposed to active smoking while only 40 of controls were exposed. Construct a 2 by 2 table to demonstrate the two dichotomous...
Read the following research study and answer the following questions: A case control study was conducted to evaluate the relationship between direct sun exposure and skin cancer. 150 Cases and 100 controls were recruited from Al Wehda hospital. A data collecting method was distributed among both controls and cases. Analysis of data revealed that 70 of cases were exposed to active smoking while only 40 of controls were exposed. Construct a 2 by 2 table to demonstrate the two dichotomous...
An investigator conducted a case-control study in 1000 participants (500 cases and 500 controls) to examine the association between childhood head trauma (exposure) and Parkinson’s disease(outcome). Information on head trauma was self-reported by study participants. Cases were able to correctly report exposure to head trauma 96% of the time, while controls correctly reported exposure to head trauma 80% of the time. Cases and controls correctly reported no exposure to head trauma 96% and 98% of the time, respectively. The truth(which...
A GWAS (Genome Wide Association Study) study is genotyping 1,000 individuals (300 controls and 700 cases) for 500,000 different SNPs in search for genes involved in the (non-fictional) disease lupus. At position 45,897,592 of chromosome 2, the measurements are as follows for a C/T SNP: -control individuals: 50 C : 550 T -case individuals: 200 C : 1200 T 2.1) Is one allele more frequent among the cases compared to the controls? Which one? 2.2) To test if the difference...
Question 28 0 out of 2 po n a case-control study of osteoporosis, 150 women were enrolled as cases and an equal number as controls. Among the cases 50 reported low calcium intake, while only 20 of the controls reported low calcium intake. Calculate the odds ratio in the association between low calcium intake and developing osteoporosis in this population.