Question

1. Explain several methods through which tyrosine kinase receptors can be activated

2. what process would activate this in endothelial cells?

Answer 1

1. Tyrosine kinases function in a variety of processes, pathways, and actions, and are responsible for key events in the body. The receptor tyrosine kinases functionin transmembrane signaling, whereas tyrosine kinases within the cellfunction in signal transduction to the nucleus. Tyrosine kinase activity in the nucleus involves cell-cycle control and properties of transcription factors.The receptor tyrosine kinases function in transmembrane signaling, whereas tyrosine kinases within the cell function in signal transduction to the nucleus.

2.Activation in the endothelial cell is entails a stereotyped series of processes, although their effects are diverse and are seen differently by specialists in different disciplines. Immunologists study upregulation of surface antigens and adhesion molecules, while those in thrombosis research assess prothrombotic endothelial cell changes, and vascular biologists study changes in tone. All these effects, however, are components of endothelial cell activation and mutually interact in causing local inflammation.

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