Briefly explain the mechanism of action of the following complementary regulatory proteins. Indicate which pathway(s) each...
Briefly explain the mechanism of action of the following complementary regulatory proteins. Indicate which pathway(s) each protein regulates. (6 points) a. C1 inhibitor b. C4bBP c. DAF d. CD46 e. CD59 f. Carboxypeptidase N
Homework Answers
a. C1 inhibitor regulates classical pathway of complement system wherein it irreversibly inhibits C1r and C1s proteases in the C1 complex of the classical complement pathway. Thus it functions in preventing spontaneous activation of complement system. It also inactivates MASP1 and MASP2 proteases in Mannose Binding Lectin pathway.
b. C4b binding protein accelerated the decaying of C3 convertase and also help in cleavage of C4b and C3b. It specifically inhibits C4 thus inhibiting classical and lectin pathway.
c. DAF or decay acceleration factor inhibits "assembly of C3 convertase" by causing the dissociatión of C2a and Bb.
d. CD46 is also a regulatory protein of complementary system it cleaves the C3b and C4b components of complement system.
e. CD59 is also called MAC inhibitory protein and regulates the formation of membrane attack complex. It binds tightly to C5b-8 complex and prevent addition of C9 molecules in the complex.
f. Carboxypeptidse N specifically cleaves the harmful and deleterious peptides.
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