Question

Hypothesize: How would a hydrophilic drug be loaded into a hydrophobic artificial liposome, and how would lipid composition affect liposome properties and drug delivery?

Answer 1

Generally Liposomes are the vesicles which is composed by the bilayer surrounding a hollow core into which the drugs and or any other molecules can be loaded for a delivery to tumors and for the cure of the diseases. Liposomes carry both hydrophobic and hydrophilic drugs and a molecules for the target test . I loaded the hydrophilic drug into the hydrophobic artificial Liposomes but there is some problem also to improve the drug to lipid ratio . A fixed amount of artificial lipid and increase the hydrophilic drug amount in it . During the manufacturing process the hydrophilic material can be dissolved in the aqueous core and hydrophobic material made to associate with the bilayer . Liposomes can be used to carry the hydrophilic and hydrophobic drugs ingredients . The presence of surfactants in a formulation which compromise the activity and intergity of artificial Liposomes so the lipid composition is also affected the drug delivery . For the injactable Liposomes formulation , the Liposomes can be freeze and dried and sampled with a suitable carrier medium .

Properties of lipid composition which affect Liposomes and drug delivery :-

pH of the formulation: A finished-formulation pH of 6.5 is ideal, because, at this pH, the rate of lipid hydrolysis is lowest.

Storage temperature: Liposomes are very susceptible to temperatures that promote oxidation and leakage of the entrapped cargo. Therefore, storage at 2-8 °C is ideal.

Container-closure system: Liposomes are not compatible with certain plastic materials. For injectable liposome suspensions, testing compatibility with the elastomeric stoppers to be used with the injection vials is essential.

Infusion tubing: For infusible liposomeformulations, establishing compatibility of the liposome suspensions with intravenous. The product label needs to specify the parts/types of tubing that can be used during drug administration.