Question

Shortly after the initiation of DNA replication at the Origin of Replication, an antibiotic has inactivated the RNA primate. In this condition, the synthesis of which new DNA strand at the replication fork would be interrupted?

A. Leading strand

B. Lagging strand

C. Both strands

D. None of the strands

Answer 1

Answer=(B) Lagging strand

Explanation-

Free 3'OH is necessary for the initiation of DNA replication in both of the strand (Lagging strand and Leading Strand) but leading strand required only an initial primer while lagging strand required multiple primers.

Now consider other option-

A) Leading Strand-

Leading strand required only an initial primer and question says initiation already started so incorrect option.

C)Both strands-

Only lagging strand affected by antibiotics so incorrect option.