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Which molecule involved with the lac operon senses glucose levels? Which senses lactose levels?

Which molecule involved with the lac operon senses glucose levels? Which senses lactose levels?

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Ans. In lac operon which is present in the E. coli, the molecule that is involved in sensing of glucose level is CAP molecules. CAP stands for Catabolite Activator Proteins. It senses the glucose when glucose level is very low and then activates the transcription of the operon. CAP does not sense the glucose level directly but through the cAMP molecules indirectly. cAMP molecules is also called as the hunger signal.

The lactose level in the lac operon is sensed by the lac repressor. The lac operon is generally blocked by the lac repressor but when the lactose is present, it stops acting as the repressor. lac repressor sense lactose level indirectly through allolactose.

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