Explain the relationship between PI(4,5)P2, DAG, PLC activation and TRPC channels (Ca2+). How are they all...
Explain the relationship between PI(4,5)P2, DAG, PLC activation and TRPC channels (Ca2+). How are they all related , what do they cause/lead to and where do I(4,5)P2 & DAG come from?
Homework Answers
/ DAG
pathway is one of the major pathway that can transduce the
signal from the activated receptor tyrosine kinase (RTK), a
cell-surface receptor.
The RTK can initiate the / DAG pathway
by activating phospholipase C-
(PLC-),an
isoform of phospholipase C. The PLC- possesses the
SH2 domain that binds particularly to the phosphotyrosines of the
activated receptors thereby positioning the enzyme in close
proximity of the membrane bound substrate PIP2.
After activation, the membrane bound PLC- cleaves PIP2
that leads to generation of two second messenger, DAG and .
The generation of leads to
activation of receptor
present on the smooth endoplasmic reticulum, this facilitate the
release of intracellular calcium stores. Transient Receptor
Potential-Canonical or TRPC channel are involved in calcium
movement.
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