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1a) What is the total possible number of TCRs that can be generated by combinatorial diversity...

1a) What is the total possible number of TCRs that can be generated by combinatorial diversity alonefrom a TCRβ locus containing 50 V, 10 D and 2 J gene segments, and a TCRα locus containing 30 V and 3 J gene segments?

  1. 90
  2. 1000
  3. 1900
  4. 9000
  5. 9.0 x 104
  6. 9.0 x 107

1b) In the previous example (question 12), what is the estimated TCRβrepertoire (i.e. total number of unique TCRβchains) if the junctional diversityper each VDJ rearrangement is 9 x 106?

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