Question

1. a. You have learned that all of the TCA intermediates are gluconeogenic precursors. Starting with two molecules glutamate in the mitochondrial matrix, show the reactions leading to formation of a molecule of glucose starting with the way glutamate enters TCA and continuing through TCA and gluconeogenesis. Be sure to include transport processes if necessary. Include structures and names of reactants and products, name of cofactors and enzymes; be as complete as possible (6 pts). [insert scan of reactions here] b. Identify the reactions you have shown which would be regulated and identify the type and specifics of regulation for each of these steps (4). [insert scan of reactions here] c. What would be the overall net reaction for synthesis of one molecule of glucose starting with two molecules of glutamate? Show your work, step by step, for coming up with this net overall reaction.

Answer 1