Question

Purine and pyrimidine metabolism require specific sources of carbon and nitrogen atoms. What are these sources for each of the classes of nucleotides?

Answer 1

Ans- The sources of carbon and nitrogen atoms in the two nucleotides are-:

a) For purine ring-

-> Glycine provides 2 Carbon atoms and 1 Nitrogen atom.

-> Glutamine provide 2 Nitrogen atoms.

-> Aspartic acid provides 1 Nitrogen atom.

-> Formyl groups provide 2 Carbon atoms.

b) For Pyrimidine formation-

-> Aspartate provides 3 Carbon atoms and 1 Nitrogen atom.

-> Carbamoyl phosphate provides 2 Carbon and 3 Nitrogen atoms.

-> Bicarbonates also provides Nitrogen atoms.

Answer 2

Metabolism of purine and pyrimidines does not produce