Question

True or False:

a. Glucuronidation is the main type of Phase I metabolism.

b. Glutathione conjugation is the most common type of Phase II metabolism.

c. Drugs must undergo Phase II metabolism to leave the body.

d. When a drug is metabolized, it will always become less potent.

e. Drugs administered intravenously largely undergo first-pass metabolism.

f. All metabolism requires enzymes.

Answer 1

a. False, because Phase II metabolism include glucuronidation.

b. True.

c. False, Because some drugs undergo only phase I or phase II metabolism, but most undergo phase 1 metabolism followed by phase 2 metabolism.

d. False, because some active metabolites of drugs have equal or better potency.

e. False, because the oral administration of drugs mainly undergo first pass metabolism, so intravenous route is preferred in case of bypassing the first pass metabolism.

f. True.