Question

3. Why are some tissues more vulnerable to inhibition of PDC activity and how does this selective tissue vulnerabilitv explain the cardinal clinical manifestations of the disease?

Answer 1

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 2

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 3

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 4

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 5

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 6

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 7

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 8

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 9

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 10

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc.

Answer 11

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 12

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 13

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 14

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.

Answer 15

The PDC deficiency cause lactic acid accumulation in the body part. In the absence of deficiency of PDC, the pyruvate will be unable to convert into acetyl Co- A and hence the pyruvate undergoes anaerobic respiration to form lactic acid leading to the damage of the tissue in absence of energy in form of ATP. In this case the body unable to break down nutrients efficiently and no ATP is formed to be used for energy.

Some cells are more vulnerable to the PDC deficiency because they are totally relied on the presence of glucose that undergo glycolsis and then enter the TCA cycle and ATP formed which is used for proper function. Tissue like brain is such example that utilizes only glucose as a source of energy aerobically. So it is highly vulnerable to the PDC dysfunction or deficiency.

Clinical manifestations: metabolic dysfunction(lethargy and increased breathing rate), neurological dysfunction (ataxia, hypotonia, developmental delay, abnormal seizures), brain abnormalities, low birth weight in infants, frontal bossing in babies etc,.