How does RSTK signal transduction differ from RTK and GPCR signaling? (Drawing a table may help)
- How does RSTK signal transduction differ from RTK and GPCR signaling? (Drawing a table may help)
Homework Answers
| Receptor Serine/Threonine Kinases | Receptor Tyrosine Kinases | G-Protein-Coupled Receptors |
| Receptor serine/threonine receptors transduce signals for the TGF-beta family | IT is a cell surface receptor that binds and respond to growth factors such as fibroblast growth factors (FGF) | It interacts with G proteins in the plasma membrane. |
| They perform inhibitory as well as stimulatory signal action for growth and differentiation by binding to members of the transforming growth factor‐β (TGF‐β) superfamily. | Binding of a signaling molecule with an RTK activates tyrosine kinase in the cytoplasmic tail of the receptor which then launches a series of enzymatic reactions that carry the signal to the nucleus. |
Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. |
| Transduce signals by means of serine/threonine. | Transduce signals by means of tyrosine kinase activity. | GPCRs transduce signals by means of heterotrimeric G proteins. |
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How does RSTK signal transduction differ from RTK and GPCR
signaling? (Drawing a table may help)
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