Question

opts). Given your knowledge of splicing regulation, what do you Chesize is going on? How do you propose the change in exon 31 is changing splicing regulation so that the products are altered as above? In your answer include any trans splicing regulatory factors involved. 32-11

Answer 1

RNA Splicing is the process A in which The introns in the RNA are removed and exons are joined by using Ceroin specific splicing machinery in the cens All the given options mentioned in the perta question results if splrcing is lost Hence option a is correct B RNA splicing is the prouss in which the introns in RNA ore removed and exons are joined by using certain specific - Splrcing machinery in Cens. If the emors in Splicing ocear in tumor Genes a tumor suppressing genes thes - concer might be showed up. All the options given are correct option is correct

RNA Splicing is the process A in which The introns in the RNA are removed and exons are joined by using Ceroin specific splicing machinery in the cens All the given options mentioned in the perta question results if splrcing is lost Hence option a is correct B RNA splicing is the prouss in which the introns in RNA ore removed and exons are joined by using certain specific - Splrcing machinery in Cens. If the emors in Splicing ocear in tumor Genes a tumor suppressing genes thes - concer might be showed up. All the options given are correct option is correct

RNA Splicing is the process A in which The introns in the RNA are removed and exons are joined by using Ceroin specific splicing machinery in the cens All the given options mentioned in the perta question results if splrcing is lost Hence option a is correct B RNA splicing is the prouss in which the introns in RNA ore removed and exons are joined by using certain specific - Splrcing machinery in Cens. If the emors in Splicing ocear in tumor Genes a tumor suppressing genes thes - concer might be showed up. All the options given are correct option is correct

Caretaker Genesi Caretaker genes encode Products that Stabilize the genome Hindamentally mutations in caretaker genes - lead to Genomic instability - lumor ceus ance from two distinct classes of Genomic instability - Noutational instaablity arising mom Changes in the nucleotide sequence of DNIA 2. Chromosomal instability arising from improper rearongement of chromosomes. Examples Caretaker genes includes Alucleonove erlision repair: is -Base excision repan - Non homologous end joining recombination pathways maismatch repair pothways and telomere metabolism.

328/37 Gore Keeper Genes: Gote keeper Genes encode products that act no Prevent growth of potential cancer cous and prevent accumulation of merations that arectly lead to increased comma Proliferation Example: Gate keeper genes includes a Bolance of Ceer growth over cellular death . remains in check insi In mutations of other genes do not lead to ongoing growth imbalances. The Apo Gene is first associated as a Gole keeper genen tai It is tumor suppressor that is consistently found to be muted in colorectal tumors Gatekeeper genes are in tact Specific to the tissues in which they reside . ali nalo In apoptosis usually senses as a mechanism to prevent excessive Cellular growth in To neoplasia while in a poroller Cell that bod no mutations in the gate Keeper functionell Simnie cen deoth woond ensue vel SANA

48 week /36 Function of BRCA1: BRCA1 is a part of a comples that repairs double - Strand Streaks. th. DA Clin homologous recombinetton -The BRCA2 proten interacts with RADST during repair of DNA double strona breaks These breaks con be caused by noturc! radiation or other exposures but also occer whes Chromosomes encenenge genetic motenar: (1/2_In mors motch repair - BRCA1 interoits with the DNA mismatch repair proteins MSH2-bin MSH MASH6 IPARD and some other proteins involved in Single Strand repair ore repored to be exevoed in BRCA1 de feerenti i mammory tumors BRCA1 directly binds to DNA witch higher affinity for bronched DNA Struttures BRCA1 to promvee laver sfidelity DNA repair by hon. homologous end joining. I Fonction Of BRCA2! Like BRCA1 BRCA2 also include in DNA repor- BRCA2 binds the single strand DNA and directly interots with the recombinase RADS! to stimulate Strond invasion avtal step of homo 10gous recombination By repolring DNA, these prowins ploy a role in mointaining the Stobility of the haman genome and Prevent dangerous e rearrangements

330135 8.week ( Embryo development: C Like BRCAI , BRCAZ Probably regulotes the activity of Other Genes and plous a critical role in embryo development