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You note that stimulation of a cell with a specific hormone leads to increased expression of...

You note that stimulation of a cell with a specific hormone leads to increased expression of a certain gene. You also find that the hormone effect can be inhibited with pertussis toxin. Describe the pathway from hormone to gene that is responsible for this process (a schematic is preferable). Indicate where in your pathway and how/why pertussis toxin has its effect.

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Answer:- G protein pathway is get effected by pertussi toxin. G protein couple receptor when boind to ligand ( external stimuli like hormone) get activated and through series of reaction activate gene expression. pertussis toxins binds to alpha sub unit of GDP and inhibit it and subsequently deactivate following pathway of gene expression. please refer below image for detailed pathway.

GPCR ligand ooooodbodoodoooooo0000000000000oood Liitilinii initi nnn ooooOQQQQQQ0000000000000000 millilit in na AC OC GTP CAM

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