Question

The classic “beads-on-a-string” structure is the most decondensed chromatin structure possible and is produced experimentally. Which chromatin components are not retained when this structure is generated?

(a) linker DNA

(b) nucleosome core particles

(c) linker histones

(d) core histones

Another person asked the question and (a) was chosen as the answer but it had multiple thumbs down.

Answer 1

The correct answer is c) linker proteins

The linear arrays of spherical structures are referred to as beads on a string and these spherical structures are termed as nucleosomes. The nucleosomes contain equal amounts of each histone except H1. The histone proteins form an octamer of two molecules each of H2A, H2B, H3, and H4, and the DNA molecule is wrapped around it. The linker DNA joins the individual nucleosome to one another. one histone not found in the core octamer of the nucleosome is H1, collectively called as linker histones.