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Where do B cells undergo somatic hypermutation and class-switching? A. germinal centers B. primary foci C....

Where do B cells undergo somatic hypermutation and class-switching?

A. germinal centers

B. primary foci

C. in the periphery, as plasma cells outside the secondary lymphoid tissues

D. in the primary lymphoid follicle

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Answer #1

Somatic hypermutation means accumulation of mutation for some change in the B cells which helps it in differentiating into plasma and mature B cells. Class -switching also happens alongside it to produce various antibodies. All these happen in Germinal centers of secondary lymphoid organs. So the correct answer is

A. Germinal centers

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