Question

Explain the underlying molecular and immunological basis of coeliac disease.

Answer 1

egeline disease Coeliac disease is caused by inflammatory, gluten specific T cell responses an small entestine. The immune reaction to eating gluten found in wheat, barley and rye, which creates inflammation that damages the small intestine's lining, leading to : comprication of small intestine. It also prevents absorption of some nutrients. Absorption of some gluten from small intestine can bind ! to HLA-DQ2 of HLA-DQ-8 and induce T cell responses. In addition, modification of gluten peptides by the enzyme tissue transglutaminase results in high affinity cell peptides that can induces T HLA-DQ2/8 binding responses. This over reaction of immune system damage the villi of small intestine, gluten Mucosal A destruction, TNFQ. INF. NF, INF. productim 7 EDAT Bell APC Cantigen cus presenting and Gluten Genetic factor | THLALDO 2/8 Epithelium 2 linnate response and adaptive response Auto antibod productim Mucosal I destruction 1 Environmental | factor GI and systemic manifestation fig: " Molecular and immunological basis of colline disease,