Are there any other alternative testing methods for a chemical's mutagenicity?
Are there any other alternative testing methods for a chemical's mutagenicity?
Homework Answers
Chemical mutagenicity (use of certain mutagenic substances like EMS or MMS or other potent mutagens which can alter the DNA sequence in an organism) in an organism can be investigated by several methods.
- Wing spot test using Drosophila as a model organism (in vivo model); phenotypic mutations can be seen by this method
- Comet assay (also known as single cell gel electrophoresis) for measurement of single strand break and double strand break (2 types, alkaline and neutral assay)
- Ames test in microbes
- Analysis of chromosomal aberration in organisms: addition, deletion, translocation and inversion etc.
We can use these alternative methods for the mutagenicity assessment using plant or animal models.
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Are there any other alternative testing methods for a chemical's
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Solve the exercise with simplex method. Using matrices or other
alternative methods is not permitted.
TIP: Remember to first eliminate any and all possible rows and
columns before you begin the simplex method. The matrix will
contain dominant strategies that can be eliminated and every
strategy that you successfully eliminate will make the simplex
method stage of the exercise easier and quicker.
Solve the following matrix game by using simplex method. 3 A/B 12 1 -1 2 22 313 a)...
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