(Molecular Biology) What is the functional difference between the major and minor grooves of DNA -...
(Molecular Biology) What is the functional difference between the major and minor grooves of DNA - and which one does protein bind to in a sequencing specific manor and how is it able to do this ALSO Name and briefly describe a specific protein(for example, SONIC HEDGEHOG (SSH)) that binds in the major groove.
Homework Answers
As the Width of the Major Grooves are more than Minor Grooves, generally the edges of the bases are more exposed in case of major groove than in case of minor grooves. As a result of this specific DNA binding proteins that can specifically bing to the double stranded DNA such as regulatory proteins and transfcription factors, generally makes contact with the exposed edges of the bases of major grooves.
Protein Binds to Major grooves in a sequence specific manner. and they are able to do this by interacting with the edges of bases which are more exposed in case of major grooves.
Most of the transcription factors such as centromere protein B (CENP-B), octamer (Oct)-1, growth factor independence 1 (Gfi-1), and WRKY bind to the major groove of DNA.
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(Molecular Biology) What is the functional difference between
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