Homework Answers
- B-cell lymphoma-extra large (Bcl-xL) protein is involved in the anti- and pro-apoptotic activity as its tBH1, BH2 and BH3 domains form a hydrophobic cleft, which is the site for interactions with the pro-death proteins, Bax and Bak.
- The NMR solution structure of Bcl-xL bound to a Bak BH3 domain peptide shows the Bak peptide forms an amphipathic α-helix, which binds via the hydrophobic side chains of the Val74, Leu78, Ile81 and Ile85 residues ( as evident from pic) into a hydrophobic groove on the surface of Bcl-xL
- Terephthalamide mimics α-Helix side chain interactions of the Bak peptide as Bcl-xL inhibitors as it inhibits the BH3 domain of Bak binding to Bcl-xL
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3. Why are terephthalamide (right) based compounds able to disrupt Bak/Bcl-XL (left) protein-protein interaction? (3 points)....
For the convex hull algorithm we have to be able to test whether a point r lies left or right of the directed line through two points p and q. Let = (px, Py), q , and r-(Tx,rv). a. Show that the sign...
For the convex hull algorithm we have to be able to test whether a point r lies left or right of the directed line through two points p and q. Let = (px, Py), q , and r-(Tx,rv). a. Show that the sign of the determinant 1 rx iy determines whether r lies left or right of the line.
For the convex hull algorithm we have to be able to test whether a point r lies left or right of...
Rank the following compounds from largest RF (on the left) to smallest Rf (on the right)...
Rank the following compounds from largest RF (on the left) to smallest Rf (on the right) in a TLC run with hexanelethyl acetate mobile phase. OH Di O I>II>11 ||I>II> 111>I>II 11>I>I|| A reaction was carried out between maleic anhydride (MA) and anthracene (A). The final reaction mixture (R) and samples of both starting materials were spotted on a TLC plate and run. Which plate shows that the reaction mixture contains a new product and maleic anhydride as excess reagent?...
pls answer 6 and 7 6. Secondary structure (turn): The image below is of a polypeptide...
pls
answer 6 and 7
6. Secondary structure (turn): The image below is of a polypeptide in secondary (20) structure level of protein folding. Specifically it is of a turn. Turns vary in length. The shorter the turn the more drastic the angle changes. The longer the turn, the more gradual the angles needed. a. Name the specific bond/interaction indicated by the dotted lines. b. Is this bond/interaction covalent or non-covalent? Is this bond/interaction permanent or transient? d. What parts...
QUESTION 1 To study how proteins fold, scientists must be able to purify the protein of...
QUESTION 1 To study how proteins fold, scientists must be able to purify the protein of interest, use solvents like urea to denature the folded protein, and observe the process of refolding at successive time points. What is the effect of the solvents used in the denaturation process? a. The solvents break all noncovalent interactions. b. The solvents break all covalent interactions. c. The solvents create a new folded conformation. d. The solvents break some of the noncovalent interactions, resulting...
I am a little confused if I have done this question right, would anyone be able...
I am a little confused if I have done this question right, would
anyone be able to check if I answered my questions right and if I
did anything wrong explain why. Thank you!!
Shown below is a plot of the radial probability distribution, 415r2R2, as a function of radial distance,r, for an atomic orbital of hydrogen. This orbital has precisely two angular nodes, with one angular node perpindicular to the x-axis, and the second angular node perpendicular to the...
please write the right answer and why these answers are wrong. 3. (6 points) In a...
please write the right answer and why these answers are
wrong.
3. (6 points) In a lab experiment involving inorganic syntheses of molecular precursors to organometallic ceramics, the final step of a five-step reaction involves the formation of a metal-metal bond. The probability of such a bond forming is p = 0.20. Let X equal the number of successful reactions out of n = 25 such experiments. (a) Find the probability that the metal-metal bonds form in at least 6,...
It has been claimed that, on average, right-handed people have a left foot that is larger...
It has been claimed that, on average, right-handed people have a left foot that is larger than the right foot. Here we test this claim on a sample of 10 right-handed adults. The table below gives the left and right foot measurements in millimeters (mm). Test the claim at the 0.05 significance level. You may assume the sample of differences comes from a normally distributed population. Person Left Foot (x) Right Foot (y) 1 272 272 2 269 267 3...
Foot-Length: It has been claimed that, on average, right-handed people have a left foot that is...
Foot-Length: It has been claimed that, on average, right-handed people have a left foot that is larger than the right foot. Here we test this claim on a sample of 10 right-handed adults. The table below gives the left and right foot measurements in millimeters (mm). Test the claim at the 0.01 significance level. You may assume the sample of differences comes from a normally distributed population. Person Left Foot (x) Right Foot (y) difference (d = x − y)...
3. An indifference curve is a. the set of all points of consumer equilibrium as the...
3. An indifference curve is a. the set of all points of consumer equilibrium as the consumer's income changes. b. all combinations of goods X and Y that yield the same total utility. c. all combinations of goods X and Y that yield the same marginal utility. d. the set of all goods that the consumer can afford given her income and the prices of the goods. 4. Which of the following is NOT a property of an indifference curve?...
A system consists of two particles of mass mi and m2 interacting with an interaction potential...
A system consists of two particles of mass mi and m2 interacting with an interaction potential V(r) that depends only on the relative distancer- Iri-r2l between the particles, where r- (ri,/i,21) and r2 22,ひ2,22 are the coordinates of the two particles in three dimensions (3D) (a) /3 pointsl Show that for such an interaction potential, the Hamiltonian of the system H- am▽ri _ 2m2 ▽22 + V(r) can be, put in the form 2M where ▽ and ▽ are the...
For the convex hull algorithm we have to be able to test whether a point r lies left or right of the directed line through two points p and q. Let = (px, Py), q , and r-(Tx,rv). a. Show that the sign of the determinant 1 rx iy determines whether r lies left or right of the line.
For the convex hull algorithm we have to be able to test whether a point r lies left or right of...
Rank the following compounds from largest RF (on the left) to smallest Rf (on the right) in a TLC run with hexanelethyl acetate mobile phase. OH Di O I>II>11 ||I>II> 111>I>II 11>I>I|| A reaction was carried out between maleic anhydride (MA) and anthracene (A). The final reaction mixture (R) and samples of both starting materials were spotted on a TLC plate and run. Which plate shows that the reaction mixture contains a new product and maleic anhydride as excess reagent?...
pls
answer 6 and 7
6. Secondary structure (turn): The image below is of a polypeptide in secondary (20) structure level of protein folding. Specifically it is of a turn. Turns vary in length. The shorter the turn the more drastic the angle changes. The longer the turn, the more gradual the angles needed. a. Name the specific bond/interaction indicated by the dotted lines. b. Is this bond/interaction covalent or non-covalent? Is this bond/interaction permanent or transient? d. What parts...
I am a little confused if I have done this question right, would
anyone be able to check if I answered my questions right and if I
did anything wrong explain why. Thank you!!
Shown below is a plot of the radial probability distribution, 415r2R2, as a function of radial distance,r, for an atomic orbital of hydrogen. This orbital has precisely two angular nodes, with one angular node perpindicular to the x-axis, and the second angular node perpendicular to the...
please write the right answer and why these answers are
wrong.
3. (6 points) In a lab experiment involving inorganic syntheses of molecular precursors to organometallic ceramics, the final step of a five-step reaction involves the formation of a metal-metal bond. The probability of such a bond forming is p = 0.20. Let X equal the number of successful reactions out of n = 25 such experiments. (a) Find the probability that the metal-metal bonds form in at least 6,...
3. An indifference curve is a. the set of all points of consumer equilibrium as the consumer's income changes. b. all combinations of goods X and Y that yield the same total utility. c. all combinations of goods X and Y that yield the same marginal utility. d. the set of all goods that the consumer can afford given her income and the prices of the goods. 4. Which of the following is NOT a property of an indifference curve?...
A system consists of two particles of mass mi and m2 interacting with an interaction potential V(r) that depends only on the relative distancer- Iri-r2l between the particles, where r- (ri,/i,21) and r2 22,ひ2,22 are the coordinates of the two particles in three dimensions (3D) (a) /3 pointsl Show that for such an interaction potential, the Hamiltonian of the system H- am▽ri _ 2m2 ▽22 + V(r) can be, put in the form 2M where ▽ and ▽ are the...
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