Question

1. In the degradation of amino acids in muscle NH4+ is carried to the liver for...

1. In the degradation of amino acids in muscle NH4+ is carried to the liver for conversion into urea by:

A. asparagine.
B. any amino acid.
C. glutamine.
D. either alanine or glutamine.
E. alanine.
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Answer #1

In muscles, the enzyme alanine aminotransferase transfers NH4+ (obtained from the deamination of amino acids) to pyruvate to form alanine, which is then transferred to the liver. The correct answer is the option E, i.e. alanine.

A similar process in brain and some other tissues transfers NH4+ to glutamate to form glutamine, which is then used in different biosynthetic pathways or transferred to the liver.

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