Question

1. The expression of the GLUT-1 glucose transporter usually correlates with the rate of anaerobic glycolysis. The number of cancer cells show increased synthesis of the GLUT-1 transporter due to c-Myc and HIF-1 alpha. Why would cancer cells need to increase the synthesis of the glucose transporter?

2. Given what you know about the rates of ATP production by glycolysis and the citric acid cycle, propose two reasons why many cancer cells preferentially use glycolysis for ATP production.

3. In addition to energy needs, cancer cells also need metabolic intermediates for biosynthesis. Explain how increased reliance on glycolysis would be beneficial in this respect.

4. Glycolysis offers a growth advantage to cancers growing under hypoxic conditions. Why might this be the case?

Answer 1

SOLUTION in cancer ansportea synthesis increases cells because : → Glucose helps in the generation of biomass and regulates cellulae signalling critical for oncogenic roguession. | Glucose is a major source of energy in cells and is a precursor of amino acides. According to waubung phenomenon, cancer cells I resort to preferential use of glycolysis as a means of generating ATP even in the presence of oxygen. GLUTS ensure that there is constant availability of I glucose for metabolism by controlling the I movement of glucose between intracellular and extracellulas compartments →ll Glycolysis in hypoxic conditions facilitates the incorporation of nutrients essential for cell proliferation into biomass, which gives an added growth advantage to cancer celles-