Question

1.Which of the following modification marks a protein for degradation in proteasomes?

A.) Phosphorylation B.)ubiquitinylation C.) acetylation D.) glycosylation

2. A reaction with a positive ∆G value can be made energetically favorable by increasing the

A.) Delta G B.)starting concentration of products C.) strting concentration of freactants (substrates) D.) a or b

Answer 1

(b) modification marks a protein for degradation in proteasomes: - The modification of proteins by chains of ubiqultin has long been known to mediate targeting of upto solic and nuclear protein for degradation by proteasomes. Proteasomes are multiprotein complexes founs in the cystal and the nuculus. Desleite this localization proteasomes do not digess culuar proteins indicrinately, but rather participate in the regulated breakdown of proteins that have been altebed so as to be suscribtible to degradation. A reaction with a positive duet a value can be made energetically favourable by increasing the stating concentration of reactants.