Explain how a low ATP allows PFK-1 to catalyze the Fuctose-6 phosphate to Fructose 1,6-bisphosphate, while...
Explain how a low ATP allows PFK-1 to catalyze the Fuctose-6 phosphate to Fructose 1,6-bisphosphate, while a high ATP inhibits that reaction.
Homework Answers
ATP is an allosteric inhibitor of Fructose 1,6-bisphosphatase enzyme.
In presence of high ATP concentrations, the Km (Michaelis constant-an inverse measure of affinity and require the high substrate concentrations to achieve maximum reaction velocity) for fructose 1,6-bisphosphate is increased, therere glycolysis stops.
ATP show this effect by binding to specific regulatory site which is distinct from the catalytic site .
AMP reverses this inhibitory action of ATP and so the activity of the enzyme increases when ATP/AMP ratio gets reduced and glycolysis is stimulated energy charge falls.
Add Answer to:
Explain how a low ATP allows PFK-1 to catalyze the Fuctose-6
phosphate to Fructose 1,6-bisphosphate, while...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
the enzyme hexokinase can catalyze the following reaction: fructose + ATP -> fructose 6 phosphate +...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____...
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____ 2. Synthesis of glucose from noncarbohydrate precursors _____ 3. Stage in which two molecules of ATP are consumed _____ 4. This is formed from pyruvate in yeast and several other microorganisms through fermentation _____ 5. The isomerization of glucose 6-phosphate to fructose 6-phosphate is a coversion of an aldose into a …._____ 6. Pyruvate is converted by pyruvate carboxylase into this intermediate _____ 7....
Training Question 3. Shown below is the activity profile for the enzyme phosphofructokinase-1 (PFK-1) which catalyzes...
Training Question 3. Shown below is the activity profile for the enzyme phosphofructokinase-1 (PFK-1) which catalyzes the reaction: Fructose 6-phosphate + ATP → fructose 1,6-biphosphate + ADP. Low (ATPI PFK-1 activity High (ATP) [Fructose 6-phosphatel Describe the different patterns of regulation for different ATP levels. Explain the why such regulation is appropriate for this enzyme, given its role in metabolism.
How many ATP are formed from the complete oxidation of fructose 1,6 bisphosphate in cells where...
How many ATP are formed from the complete oxidation of fructose 1,6 bisphosphate in cells where the malate-aspartate shuttle is active?
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are...
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are regulated & compare their regulation in liver vs. skeletal muscle & brain when blood glucose levels are high (i.e. a fed state) & low (i.e. a fasting or starvation state).
How does Fructose 2,6-bisphosphate regulate PFK-1?
How does Fructose 2,6-bisphosphate regulate PFK-1?
Aldolase splits fructose-1,6-bisphosphate into two compounds. One is glyceraldehyde-3-phosphate. What is the other product of this...
Aldolase splits fructose-1,6-bisphosphate into two compounds. One is glyceraldehyde-3-phosphate. What is the other product of this reaction? a. glyceraldehyde-2-phosphate b. glyceraldehyde-1-phosphate c. dihydroxyacetone phosphate d. phosphoenolpyruvate e.1,3-bisphosphoglycerate
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK...
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK catalyzed reaction as seen in graph Arch (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above B) (3 pts) What is the role of fructose 2.6-bisphosphate (F-2,6-BP) in the PFK catalyzed reaction as seen Choose between: (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above C) (4 pts) What are the 2 roles of ATP in...
A highly regulated reaction in glycolysis involves the addition of a second phosphate to fructose-6-phosphate, which...
A highly regulated reaction in glycolysis involves the addition
of a second phosphate to fructose-6-phosphate, which could be be
written as:
Fructose-6-phostphate + Pi à Fructose-1,6-bisphosphate + H2O
The ∆Go’ for this reaction is +16.8 kJ/mol
In a muscle cell at 37 oC, assume the concentration of
Fructose-6phosphate is 0.014 mM and the concentration of phosphate
is 1 mM.
a. What would be the equilibrium concentration of
fructose-1,6bisphosphate under these conditions?
b. What is Keq for this reaction?
Show...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
Training Question 3. Shown below is the activity profile for the enzyme phosphofructokinase-1 (PFK-1) which catalyzes the reaction: Fructose 6-phosphate + ATP → fructose 1,6-biphosphate + ADP. Low (ATPI PFK-1 activity High (ATP) [Fructose 6-phosphatel Describe the different patterns of regulation for different ATP levels. Explain the why such regulation is appropriate for this enzyme, given its role in metabolism.
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK catalyzed reaction as seen in graph Arch (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above B) (3 pts) What is the role of fructose 2.6-bisphosphate (F-2,6-BP) in the PFK catalyzed reaction as seen Choose between: (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above C) (4 pts) What are the 2 roles of ATP in...
A highly regulated reaction in glycolysis involves the addition
of a second phosphate to fructose-6-phosphate, which could be be
written as:
Fructose-6-phostphate + Pi à Fructose-1,6-bisphosphate + H2O
The ∆Go’ for this reaction is +16.8 kJ/mol
In a muscle cell at 37 oC, assume the concentration of
Fructose-6phosphate is 0.014 mM and the concentration of phosphate
is 1 mM.
a. What would be the equilibrium concentration of
fructose-1,6bisphosphate under these conditions?
b. What is Keq for this reaction?
Show...
Most questions answered within 3 hours.
-
Where is the error in this code sequence?
String s1 = "Hello";
String s2 = "ello";...
asked 10 months ago -
Financial data for Joel de Paris, Inc., for last year
follow:
Joel de Paris, Inc.
Balance...
asked 10 months ago -
Consider this reaction:
Al2(SO4)3 (aq)+ BaCl3
(aq) Al2Cl6 (aq)- +
3BaSO4(s) . What is the...
asked 10 months ago -
Suppose that Savneet is considering increasing her
recent random sample from 20 car rentals to 40...
asked 10 months ago -
Trucks arrive at an unloading terminal at an average rate of 120
per hour.
Trucks arrive...
asked 10 months ago -
Why are methanol and ethanol completely soluble in water while
octanol is not very little soluble....
asked 10 months ago -
A facilities manager at a university reads in a research report
that the mean amount of...
asked 10 months ago -
When the CuSO4 is rehydrated by adding water to the anhydrous
compound, is this an endothermic...
asked 10 months ago -
A ray of sunlight is passing from diamond into crown glass; the
angle of incidence is...
asked 10 months ago -
A block of mass 0.249 kg is placed on top of a light, vertical
spring of...
asked 10 months ago -
how do the kidneys compensate in the presences of acidosis
a) trigger hyperventilate
b) reserve acid...
asked 10 months ago -
Question 501 pts
The rental rate of capital to the firm increases. Which of the
following...
asked 10 months ago