How does Fructose 2,6-bisphosphate regulate PFK-1?
- How does Fructose 2,6-bisphosphate regulate PFK-1?
Homework Answers
Select all the metabolites that NEGATIVELY regulate Glycolysis. Group of answer choices Glucose-6-Phosphate Citrate Fructose-2,6-bisphosphate ATP...
Select all the metabolites that NEGATIVELY regulate Glycolysis. Group of answer choices Glucose-6-Phosphate Citrate Fructose-2,6-bisphosphate ATP 2- What are all the metabolites that POSITIVELY regulate Gluconeogeneis? Group of answer choices Fructose-2,6-bisphosphate Acetyl CoA Citrate AMP
17. Researchers have isolated a PFK-1 mutant in which a serie di ve HUWU 4,0 bisphosphate...
17. Researchers have isolated a PFK-1 mutant in which a serie di ve HUWU 4,0 bisphosphate binding site has been replaced with an aspartate. This results in absolutely no binding of fructose 2,6-bisphosphate and a decrease in glycolysis activity. Explain why the fructose 2,6-bisphosphate would no longer bind. 1 mark
MATCH THE FOLLOWING a. PFK-1 b. FBpase-1 c. PFK-2 d. FBpase-2 e.cAMP- dependent protein kinase (PKA) WITH 1. makes F-2,6 -BP(fructose-2,6-biphosphate) 2. Activated by F-2,6-BP(fructose-2,6-biphosphate...
MATCH THE FOLLOWING a. PFK-1 b. FBpase-1 c. PFK-2 d. FBpase-2 e.cAMP- dependent protein kinase (PKA) WITH 1. makes F-2,6 -BP(fructose-2,6-biphosphate) 2. Activated by F-2,6-BP(fructose-2,6-biphosphate) 3. Activates the enzyme that breaks down F-2,6-BP 4. Inhibited by F-2,6-BP 5. Breaks down F-2,6-BP
Explain how a low ATP allows PFK-1 to catalyze the Fuctose-6 phosphate to Fructose 1,6-bisphosphate, while...
Explain how a low ATP allows PFK-1 to catalyze the Fuctose-6 phosphate to Fructose 1,6-bisphosphate, while a high ATP inhibits that reaction.
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in...
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. in the level of fructose 2,6-bisphosphate. High glucagon would cause a(an) (Write either “increase” or “decrease” in that blank.) What enzyme does fructose 2,6-bisphosphate ACTIVATE? E) OK, let's go back to the first of those glycolysis steps that you said was highly regulated. Using THERMODYNAMICS terms, what is it about this reaction that...
Fructose 2,6-bisphosphate a. activates fructose 1,6-bisphosphatase. b. inhibits fructose 2,6-bisphosphatase. c. activates pyruvate kinase. d. activates...
Fructose 2,6-bisphosphate a. activates fructose 1,6-bisphosphatase. b. inhibits fructose 2,6-bisphosphatase. c. activates pyruvate kinase. d. activates phosphofructokinase. e. production is stimulated by glucagon.
PART A OPTIONS FOR BLANKS: 1- inhibits, does not affect, stimulates 2- fructose-1,6-biphosphatase-1, pyruvate kinase, phosphofructokinase-1...
PART A OPTIONS FOR BLANKS:
1- inhibits, does not affect, stimulates
2- fructose-1,6-biphosphatase-1, pyruvate kinase,
phosphofructokinase-1
3- phosphofructokinase-1, fructose-1,6-biphosphatase-1,
phosphoenolpyruvate carboxylate
PART B OPTIONS FOR BLANK:
Activity Curve A, Neither, Activity Curve B
Part 1 (3 points) See Hint High levels of fructose-2,6-BP reciprocally regulate glycolysis and gluconeogenesis. Fructose-2,6-BP flux through the glycolytic pathway by increasing the activity of Flux through the gluconeogenic pathway is inhibited by fructose-2,6- BP, which decreases the activity of Part 2 (1 point) See Hint...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK...
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK catalyzed reaction as seen in graph Arch (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above B) (3 pts) What is the role of fructose 2.6-bisphosphate (F-2,6-BP) in the PFK catalyzed reaction as seen Choose between: (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above C) (4 pts) What are the 2 roles of ATP in...
Synthesis of fructose-2,6-bisphosphate is catalyzed by a bifunctional enzyme that contains two catalytic domains: PFK2 (kinase...
Synthesis of fructose-2,6-bisphosphate is catalyzed by a bifunctional enzyme that contains two catalytic domains: PFK2 (kinase domain) and FBPase2 (phosphatase domain). How is glucose metabolism affected when the PFK2/FBPase2 enzyme is phosphorylated? Both glycolysis and gluconeogenesis occur simultaneously Glycolysis is upregulated, gluconeogenesis is downregulated Glycolysis is downregulated, gluconeogenesis is upregulated Glycolysis and glycogen synthesis are upregulated
17. Researchers have isolated a PFK-1 mutant in which a serie di ve HUWU 4,0 bisphosphate binding site has been replaced with an aspartate. This results in absolutely no binding of fructose 2,6-bisphosphate and a decrease in glycolysis activity. Explain why the fructose 2,6-bisphosphate would no longer bind. 1 mark
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. in the level of fructose 2,6-bisphosphate. High glucagon would cause a(an) (Write either “increase” or “decrease” in that blank.) What enzyme does fructose 2,6-bisphosphate ACTIVATE? E) OK, let's go back to the first of those glycolysis steps that you said was highly regulated. Using THERMODYNAMICS terms, what is it about this reaction that...
PART A OPTIONS FOR BLANKS:
1- inhibits, does not affect, stimulates
2- fructose-1,6-biphosphatase-1, pyruvate kinase,
phosphofructokinase-1
3- phosphofructokinase-1, fructose-1,6-biphosphatase-1,
phosphoenolpyruvate carboxylate
PART B OPTIONS FOR BLANK:
Activity Curve A, Neither, Activity Curve B
Part 1 (3 points) See Hint High levels of fructose-2,6-BP reciprocally regulate glycolysis and gluconeogenesis. Fructose-2,6-BP flux through the glycolytic pathway by increasing the activity of Flux through the gluconeogenic pathway is inhibited by fructose-2,6- BP, which decreases the activity of Part 2 (1 point) See Hint...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK catalyzed reaction as seen in graph Arch (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above B) (3 pts) What is the role of fructose 2.6-bisphosphate (F-2,6-BP) in the PFK catalyzed reaction as seen Choose between: (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above C) (4 pts) What are the 2 roles of ATP in...
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