Are there secondary targets (other kinases) that are inhibited by imatinib mesylate?
Are there secondary targets (other kinases) that are inhibited by imatinib mesylate?
Homework Answers
Yes, there secondary targets (other kinases) that are inhibited by imatinib mesylate. Imatinib mesylate works against the Bcr-Abl tyrosine-kinase (this is the primary target, and it stops the Bcr-Abl tyrosine –kinase). In addition, it inhibits proto-oncogene c-Kit or tyrosine-protein kinase Kit (c-kit), Platelet-derived growth factor receptors (PDGF-R) that are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family, as well as ABL2 (ARG) and DDR1 tyrosine kinases and NQO2 - an oxidoreductase. So, it also targets other kinases in addition to the Bcr-Abl tyrosine-kinase.
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Six molecular targets for drugs where described. Pick 3 of these targets and complete the table...
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D Question 22 2.2 pts In the process of cell signaling, the signaling molecule that is...
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4) A signaling pathway proceeds through three protein kinases that are sequentially activated by phosphorylation. In one case, the kinases are held in a signaling complex by a scaffold protein. In the other, the kinases are freely diffusing. Discuss the properties of these two types of organization in terms of the signal amplification, speed, and potential cross talk between signaling pathways. (10 Points)
10. Protein folding, in most cases, is complex and inhibited by aggregation. Which of the following is false regarding protein folding? A. Chaperones of the heat shock classes do not promote folding, but rather inhibit aggregation. B. Enzymes promote the formation of proper disulfide linkages by eliminating improper folding. C. All proteins require the input of energy and the assistance of chaperones for folding. D. Secondary structures usually form first in folding.
D Question 22 2.2 pts In the process of cell signaling, the signaling molecule that is specifically detected by the target cell o is called a signal transducer. o is called a polymer is known as a secondary messenger. is called a ligand. e terminates the signal reception If phosphorylation were inhibited, this would most affect the activity of G-protein-linked receptors. e ligand-gated ion channels. transcription factors e phosphatase enzymes. O receptor tyrosine kinases.
Classify the phrases. Does each phrase describe a kinase, a phosphatase, neither, or both? Kinases Phosphatases Neither Both catalyze dephosphorylation reactions add phosphoryl groups to proteins in eukaryotes, transfer phosphoryl groups to acidic amino acids may use ATP as a phosphoryl group donor regulate the activity of other proteins turn off signaling pathways triggered by kinases catalyze reactions that are the reverse of dephosphorylation reactions PKA (protein kinase A) is an example Answer Bank
How is signaling from receptor tyrosine kinases terminated? GTP hydrolysis ATP hydrolysis receptor endocytosis Arrestins Pathway crosstalk occurs when: signaling pathways use a common intermediate o signaling pathways split to produce multiple outcomes one signaling pathway triggers another signaling pathways produce the same outcome Eicosanoid hormones such as prostaglandins and leukotrienes are responsible for localized immune reactions such as to insect bites and hayfever symptoms. Which of the following best describes this level of cell signaling? Autocrine Endocrine o Holoerine...
D. Antiviral E. Antifungal 14. What type of drug is Metronidazole? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 15. What type of drug is Daptomycin? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 16. What type of drug is Amphotericin B? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other
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